2013 Fiscal Year Final Research Report
Novel strategy to awake gene cluster using small molecules that activate LAL family transcriptional regulator
| Project/Area Number |
24658088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
TAKAHASHI Shunji 独立行政法人理化学研究所, 環境資源科学研究センター, ユニットリーダー (30311608)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 休眠遺伝子覚醒 / バイオメディエーター / LALファミリー / 小分子化合物 / 転写制御因子 |
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| Research Abstract |
Genome sequencing of Streptomyces spp. revealed many unknown secondary metabolite gene clusters that might be potential sources for a medicinal drug and an agricultural chemical. The objective of the study is an activation of secondary metabolite gene clusters using small molecules. LAL family transcriptional regulators are widely found in Streptomyces spp. Among them, we focused on RevU which exists in reveromycin biosynthetic gene cluster. We searched a small molecule which activates reveromycin production, and optimized its chemical structure. This study gave great insights for the mechanism of the activation of secondary metabolite gene cluster.
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[Journal Article] RK-1355A and B, Novel Quinomycin Derivatives Isolated from a Microbial Metabolites Fraction Library Based on NPPlot Screening2014
Author(s)
Lim C. L., Nogawa T., Uramoto M., Okano A., Hongo Y., Nakamura T., Koshino H., Takahashi S., Ibrahim D., and Osada H.
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Journal Title
J. Antibiot.
Volume: 67
Pages: 323-329
DOI
Peer Reviewed
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