2013 Fiscal Year Final Research Report
Screening of food factors inducing regulatory B cells
| Project/Area Number |
24658116
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TOTSUKA Mamoru 東京大学, 農学生命科学研究科, 准教授 (70227601)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 制御性B細胞 / インターロイキン10 / フラボノイド / ケンフェロール / タマリキセチン / 芳香族炭化水素受容体（AhR） / 抗アレルギー / 抗炎症 |
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| Research Abstract |
An experimental system screening flavonoids that enhance the differentiation of mouse B cells to regulatory B cells or those activating regulatory B cells was established. Using this system, we found that kaempferol and tamarixetin upregulated interleukin-10 -producing regulatory B cells in the presence of lipopolisaccharides. Oral administration of kaempferol was found to increase the ratio of regulatory B cells in spleens and mesenteric lymph nodes of mice. Kaempferol and tamarixetin showed an antagonistic activity to aryl-hydrocarbon receptor, and the activity was suggested to contribute to the up-regulation of regulatory B cells. This study demonstrates a novel approach to develop anti-allergic and anti-inflammatory functional foods targeting regulatory B cells.
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