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2013 Fiscal Year Final Research Report

Construction of novel platform for development of functional food products based on next-generation integrated omics approach

Research Project

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Project/Area Number 24658129
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionKeio University

Principal Investigator

FUKUDA Shinji  慶應義塾大学, 政策・メディア研究科, 特任准教授 (80435677)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords腸内細菌 / 統合オミクス / プレバイオティクス / 腸内エコシステム / オリゴ糖 / 機能性食品 / メタボローム / IgA
Research Abstract

Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remains obscure. Taking advantage of our novel microbe-metabolite correlation approach, combined with fecal IgA measurements, we found that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific gut microbes in human trials. Furthermore, specific metabolic changes were observed positively or negatively correlated with IgA profiles. IgA is well known as an important molecule not only to prevent intestinal pathogenic infection, but also to regulate commensal gut microbiota; therefore, induction of mucosal IgA by FOS supplementation is considered to be one of the beneficial effect of prebiotics through gut ecosystem modification.

  • Research Products

    (20 results)

All 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (9 results) (of which Invited: 9 results) Remarks (1 results)

  • [Journal Article] Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation2014

    • Author(s)
      Kato, T., Fukuda, S., Fujiwara, A., Suda, W., Hattori, M., Kikuchi, J., Ohno, H.
    • Journal Title

      DNA Res.

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] In vitro evaluation method for screening of candidate prebiotic foods2014

    • Author(s)
      Date, Y., Nakanishi, Y., Fukuda, S., Nuijima, Y., Kato, T., Umehara, M., Ohno, H., and Kikuchi, J.
    • Journal Title

      Food Chem.

      Volume: 152 Pages: 251-260

    • Peer Reviewed
  • [Journal Article] Gut microbiome and metabolic diseases2014

    • Author(s)
      Fukuda, S. and Ohno, H.
    • Journal Title

      Semin. Immunopathol

      Volume: 36 Pages: 103-114

    • Peer Reviewed
  • [Journal Article] Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells2013

    • Author(s)
      Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N.N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J.M., Topping, D.L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K., Ohno, H.
    • Journal Title

      Nature

      Volume: 504 Pages: 446-450

    • Peer Reviewed
  • [Journal Article] Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing2013

    • Author(s)
      Kim, S.W., Suda, W., Kim, S., Oshima, K., Fukuda, S., Ohno, H., Morita, H., Hattori, M.
    • Journal Title

      DNA Res.

      Volume: 20 Pages: 241-253

    • Peer Reviewed
  • [Journal Article] Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice2013

    • Author(s)
      Okada, T., Fukuda, S., Hase, K., Nishiumi, S., Izumi, Y., Yoshida, M., Hagiwara, T., Kawashima, R., Yamazaki, M., Oshio, T., Otsubo, T., Inagaki, O. K., Kakimoto, K., Higuchi, K., Kawamura, Y. I., Ohno, H., Dohi, T.
    • Journal Title

      Nat. Commun.

      Volume: 4 Pages: 1654

    • Peer Reviewed
  • [Journal Article] 統合オミクスによる腸エコシステムの全容理解に向けた取り組み2013

    • Author(s)
      福田真嗣、大野博司
    • Journal Title

      細胞工学

      Volume: 32 Pages: 1138-1142

  • [Journal Article] 腸内環境とアンチエイジング2013

    • Author(s)
      福田真嗣、村上慎之介
    • Journal Title

      日本抗加齢医学会雑誌

      Volume: 9 Pages: 717-722

  • [Journal Article] Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters2012

    • Author(s)
      Fukuda, S., Toh, H., Taylor, T. D., Ohno, H., and Hattori, M.
    • Journal Title

      Gut Microbes

      Volume: 3 Pages: 449-454

    • Peer Reviewed
  • [Journal Article] 統合オミクスによる腸エコシステムの理解2012

    • Author(s)
      福田真嗣、大野博司
    • Journal Title

      実験医学

      Volume: 30 Pages: 3255-3260

  • [Presentation] 統合オミクスによる宿主-腸内細菌間相互作用の理解2014

    • Author(s)
      福田真嗣
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-30
    • Invited
  • [Presentation] Understanding the complex gut ecosystem via integrated omics approach2014

    • Author(s)
      福田真嗣
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-26
    • Invited
  • [Presentation] 腸内エコシステムの理解に慶應義塾大学・政策・メディア研究科・特任よる新たな健康増進ストラテジー2014

    • Author(s)
      福田真嗣
    • Organizer
      第3回アンチエイジングセミナー
    • Place of Presentation
      東京
    • Year and Date
      2014-01-23
    • Invited
  • [Presentation] 統合オミクスによる腸内エコシステムの理解2013

    • Author(s)
      福田真嗣
    • Organizer
      第29回日本微生物生態学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-11-24
    • Invited
  • [Presentation] Human Microbiomeと生体応答の理解による新たな健康増進ストラテジー2013

    • Author(s)
      福田真嗣
    • Organizer
      第13回抗加齢医学の実際
    • Place of Presentation
      東京
    • Year and Date
      2013-09-16
    • Invited
  • [Presentation] Comprehensive understanding of gut ecosystem via multiple omics approach2013

    • Author(s)
      Fukuda, S
    • Organizer
      International Conference of Matryoshka-type Evolution of Eukaryotic Cells
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-07-25
    • Invited
  • [Presentation] マルチオミクスによる腸内共生システムの理解2012

    • Author(s)
      福田真嗣
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Invited
  • [Presentation] Multiple omics approach identified acetate produced by probiotic bifidobacteria to protect host from enteropathogenic infection2012

    • Author(s)
      Fukuda, S
    • Organizer
      International Conference and Exhibition of Probiotics
    • Place of Presentation
      San Antonio, TX
    • Year and Date
      2012-11-19
    • Invited
  • [Presentation] Understanding the gut ecosystem via multiple omics approach2012

    • Author(s)
      Fukuda, S
    • Organizer
      The International Scientific Conference on Probiotics and Prebiotics 2012
    • Place of Presentation
      Kosice, Slovakia
    • Year and Date
      2012-06-12
    • Invited
  • [Remarks]

    • URL

      http://www.iab.keio.ac.jp/jp/

URL: 

Published: 2015-06-25  

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