A patho-physiological study on perinatal abnormalities in NC/Tnd mice

2013 Fiscal Year Final Research Report

• Project/Area Number: 24658267
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Clinical veterinary science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: MATSUDA Hiroshi 東京農工大学, (連合)農学研究科(研究院), 教授 (80145820)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 臨床病理・病態 / 羊水塞栓症 / 動物モデル

Research Abstract

NC/Tnd mice are widely used for a study on atopic dermatitis as a spontaneous model all over the world, but breeding is difficult and there are some maternal death in the third pregnancy trimester and newborn baby death at the time of the delivery. However, the cause has been unclear. The amniotic fluid embolism which has a serious influence on a perinatal mother's body brings the anaphylactic condition of a patient. Therefore, in this study, we focused on perinatal abnormality occurred in NC/Tnd mice and examined immune status of the mice during pregnancy. As a result, the blood concentration of anaphylatoxin and the platelet activating factor was higher than the standard mice. Results indicate that the Th1 immune responses in pregnant NC/Tnd mice may involve in abnormalities that are noticed during the perinatal period.

Research Products

• [Journal Article] Suppressive effect of mangosteen rind extract on the spontaneous development of atopic dermatitis in NC/Tnd mice (2013)
  • Author(s): Higuchi H, Tanaka A, Nishikawa S, Oida K, Matsuda A, Jung K, Amagai Y, Matsuda H
  • Journal Title: J. Dermatol Volume: 40(10) Pages: 786-796
  • DOI: 10.1111/1346-8138.12250
  • Peer Reviewed
• [Journal Article] Topical application of ketoprofen improves gait disturbance in rat models of acute inflammation (2013)
  • Author(s): Amagai Y, Tanaka A, Matsuda A, Oida K, Jung K, Nishikawa S, Jang H, Ishizaka S, Matsuda H
  • Journal Title: BioMed Res. Int Volume: 2013 Pages: 540231
  • DOI: 10.1155/2013/540231
  • Peer Reviewed
• [Journal Article] Increased Expression of Gelatinase and Caspase Activities in the Skin of NC/Tnd Mice : A Model for Atopic Dermatitis (2013)
  • Author(s): Kobayashi T, Hayakawa K, Tanaka A, Matsuda H
  • Journal Title: Dermatitis Volume: 24(5) Pages: 254-255
  • DOI: 10.1097/DER.0b013e31829f2895
  • Peer Reviewed
• [Journal Article] Abnormalities in itch sensation and skin barrier function in atopic NC/Tnd mice (2013)
  • Author(s): Amagai Y, Matsuda H, Tanaka A
  • Journal Title: Biol Pharm Bull Volume: 36(8) Pages: 1248-1252
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23902968
  • Peer Reviewed
• [Journal Article] Antifungal effects of palmitic acid salt and ultrapure soft water on Scedosporium apiospermum (2013)
  • Author(s): Jung K, Miyagawa M, Matsuda A, Amagai Y, Oida K, Okamoto Y, Takai M, Nishikawa S, Jang H, Ishizaka S, Ahn G, Tanaka A, Matsuda H
  • Journal Title: J. App. Microbiol Volume: 115(3) Pages: 711-717
  • DOI: 10.1111/jam.12298
  • Peer Reviewed
• [Journal Article] Daily intake of Jeju ground water improves the skin condition of the model mouse for human atopic dermatitis (2013)
  • Author(s): Tanaka A, Jung K, Matsuda A, Jang H, Kajiwara N, Amagai Y, Oida K, Ahn G, Ohmori K, Kang K, Matsuda H
  • Journal Title: J. Dermatol Volume: 40(3) Pages: 193-200
  • DOI: 10.1111/1346-8138.12055
  • Peer Reviewed
• [Journal Article] Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells (2012)
  • Author(s): Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, Jung K, Matsuda A, Tanaka A, Matsuda H
  • Journal Title: Vet. J Volume: S1090-0233 (12) Pages: 00432-00437
  • DOI: 10.1016/j.tvjl.2012.10.010
  • Peer Reviewed
• [Journal Article] Recent findings in mouse models for human atopic dermatitis (2012)
  • Author(s): Tanaka A, Amagai Y, Oida K, Matsuda H
  • Journal Title: Exp Anim Volume: 61(2) Pages: 77-84
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22531722
  • Peer Reviewed
• [Journal Article] Supplementation of the fermented soy product ImmuBalance™effectively reduces itching behavior of atopic NC/Tnd mice (2012)
  • Author(s): Matsuda A, Tanaka A, Pan W, Okamoto N, Oida K, Kingyo N, Amagai Y, Xia Y, Jang H, Nishikawa S, Kajiwara N, Ahn G, Ohmori K, Matsuda H
  • Journal Title: J. Dermatol. Sci Volume: 67(2) Pages: 130-139
  • DOI: 10.1016/j.jdermsci.2012.05.011
  • Peer Reviewed
• [Presentation] アトピー性皮膚炎治療における皮膚pH調節の重要性 (2013)
  • Author(s): 張孝善、松田浩珍, 他
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 岐阜県、岐阜大学
  • Year and Date: 2013-09-22
• [Presentation] カジメに含まれるdieckolのアトピー性皮膚炎症状に対する治療効果 (2013)
  • Author(s): 安キンネ、松田浩珍, 他
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 岐阜県、岐阜大学
  • Year and Date: 2013-09-22
• [Presentation] Influence of the potential hydrogen on skin barrier function and immune responses in NC/Tnd mice (2013)
  • Author(s): 張孝善、松田浩珍, 他
  • Organizer: a model for human AD EAACI-WAO Congress 2013
  • Place of Presentation: イタリア・ミラノ
  • Year and Date: 2013-06-23
• [Presentation] The benefits of comaparative approaches for atopic dermatitis (2012)
  • Author(s): 松田浩珍
  • Organizer: ISMA 2013
  • Place of Presentation: オーストリア・ウィーン
  • Year and Date: 2012-12-05
  • Invited
• [Presentation] アトピー性皮膚炎モデルマウスにおける皮膚pHと皮膚バリア損傷の関連性 (2012)
  • Author(s): 張孝善、松田浩珍, 他
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 岩手県、岩手大学
  • Year and Date: 2012-09-14
• [Presentation] A study on impaired-skin barrier functions in NC/Tnd mice (2012)
  • Author(s): 張孝善、松田浩珍, 他
  • Organizer: a model for human atopic dermatitis EAACI 2012
  • Place of Presentation: スイス・ジュネーブ
  • Year and Date: 2012-06-19
• [Remarks]
  • URL: http://www.tuat.ac.jp/~mol_path/