2013 Fiscal Year Final Research Report
Developmental mechanisms of viscerosensory neurons
| Project/Area Number |
24659080
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHIGA Takashi 筑波大学, 医学医療系, 教授 (50178860)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Runx転写因子 / 内臓感覚 / 迷走神経 / 細胞分化 / 神経ペプチド |
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| Research Abstract |
The roles of Runx transcription factor in the development of viscerosensory neurons were examined with special reference to nodose-jugular ganglia complex (NG-JG) and esophagus. Runx1 was expressed in medium- to large-sized neurons in NG-JG. Anaysis using Runx1-deficient mice showed that runx1 inhibits the expression of CGRP in nerve fibers in the esophagus.
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