Challenge to improve dry mouth through the TRP channel by spice

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659105
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kanazawa University
• Principal Investigator: SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
• Co-Investigator(Kenkyū-buntansha): SHIDO Osamu 島根大学, 医学部, 教授 (40175386)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 香辛料 / 暑熱順化 / ＴＲＰチャネル

Research Abstract

We realize the greatness of saliva in the meal time. However, xerostomia which saliva secretion reduction is originating increases, and xerostomia serves as a big social problem in recent years. In addition, the current situation is that elder people are brought to increase, xerostomia of the elder people can not be ignored. We showed a possibility that a warming and spices could improve the QOL of mouth dryness through this research. And I proved not a little also about the molecular mechanism. I am sure that the result of this research contributes not only to elderly people but to people troubled with xerostomia.

Research Products

• [Journal Article] Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats (2013)
  • Author(s): Sugimoto N, Matsuzaki K, Ishibashi H, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Sekine J, Koizumi S, Yachie A, Umehara H, Shido O
  • Journal Title: Sci Rep Volume: 3 Pages: 1763
  • DOI: 10.1038/srep01763
  • Peer Reviewed
• [Journal Article] Targeted activation of PKA and Epac promotes glioblastoma regression in vitro (2013)
  • Author(s): Sugimoto N, Miwa S, Tsuchiya H, Hitomi Y, Nakamura H, Yachie A, Koizumi S
  • Journal Title: Mol Clin Oncol Volume: 1 Pages: 281-285
  • DOI: 10.3892/mco.2013.65
  • Peer Reviewed
• [Journal Article] Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis (2013)
  • Author(s): Ishikawa S, Shimizu M, Ueno K, Sugimoto N, Yachie A
  • Journal Title: Cytokine Volume: 62 Pages: 272-277
  • DOI: 10.1016/j.cyto.2013.03.007
  • Peer Reviewed
• [Journal Article] Real-time Imaging ofαv Integrin Molecular Dynamics in Osteosarcoma Cells In Vitro and In Vivo (2013)
  • Author(s): Tome Y, Sugimoto N, Yano S, Momiyama M, Mii S, Maehara H, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: Anticancer Res Volume: 33 Pages: 3021-3025
  • Peer Reviewed
• [Journal Article] High Lung-metastatic Variant of Human Osteosarcoma Cells, Selected by Passage of Lung Metastasis in Nude Mice, Is Associated with Increased Expression ofαvβ3 Integrin (2013)
  • Author(s): Tome Y, Kimura H, Maehara H, Sugimoto N, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: Anticancer Res Volume: 33 Pages: 3623-3628
  • Peer Reviewed
• [Journal Article] Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy (2013)
  • Author(s): Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM
  • Journal Title: J Cell Biochem Volume: 114(11) Pages: 2454-2460
  • DOI: 10.1002/jcb.24593
  • Peer Reviewed
• [Journal Article] Lactobacillus casei cell wall extract directly stimulates the expression of COX2 independent of Toll-like receptor 2 in rat glial cells (2013)
  • Author(s): Sugimoto N, Ohta K, Saito T, Nakayama Y, Nakamura T, Maeda A, Yachie A
  • Journal Title: J Microbiol Immun Infect Volume: 46 Pages: 389-392
  • DOI: 10.1016/j.jmii.2012.03.004
  • Peer Reviewed
• [Journal Article] Transplantation of Uncultured Adipose-Derived Regenerative Cells for Peripheral Nerve Regeneration (2013)
  • Author(s): Sugamuma S, Tada K, Hayashi K, Takeuchi A, Sugimoto N, Ikeda K, Tsuchiya H
  • Journal Title: J Orthop Sci Volume: 18 Pages: 145-151
  • DOI: 10.1007/s00776-012-0306-9
  • Peer Reviewed
• [Journal Article] Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells (2012)
  • Author(s): Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A, Umehara H
  • Journal Title: Cell Physiol Biochem Volume: 3 Pages: 450-457
  • DOI: 10.1159/000339038
  • Peer Reviewed
• [Journal Article] Skewed Production of IL-6 and TGFß by Cultured Salivary Gland Epithelial Cells from Patients with Sjögren's Syndrome (2012)
  • Author(s): Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Sugimoto N, Okazaki T, Umehara H
  • Journal Title: Plos One Volume: 7 Pages: e45689
  • DOI: 10.1371/journal.pone.004568
  • Peer Reviewed
• [Journal Article] Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-κB and MAPK activations and cell proliferation through protein kinase A- or exchange protein activated by cAMP-dependent signal pathway (2012)
  • Author(s): Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomo Y, Nakamura H, Koizumi S, Yachie A
  • Journal Title: ScientificWorldJournal Volume: 2012 Pages: 748572
• [Journal Article] Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87-MG human malignant glioma cells (2012)
  • Author(s): Echigo R, Sugimoto N, Yachie A
  • Journal Title: Oncol Rep Volume: 28 Pages: 1176-1180
  • Peer Reviewed
• [Journal Article] Caffeine Induces Apoptosis of Osteosarcoma Cells by Inhibiting AKT/mTOR/S6K, NF-κB and MAPK Pathways (2012)
  • Author(s): Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 23 Pages: 3643-3649
  • Peer Reviewed
• [Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptorαchain gene between atopic dermatitis and Japanese cedar pollinosis (2012)
  • Author(s): Tanaka T, HitomiY, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, Nakamura H
  • Journal Title: Allergol Int Volume: 61 Pages: 57-63
  • Peer Reviewed
• [Presentation] 低酸素環境下でのがん細胞の動向 (2014)
  • Author(s): 杉本直俊、少作隆子、松崎健太郎、片倉賢紀、紫藤治
  • Organizer: 第9回環境生理学プレコングス
  • Place of Presentation: 国民宿舎レインボー桜島(鹿児島県)
  • Year and Date: 2014-03-15
• [Presentation] 食と若返り (2013)
  • Author(s): 杉本直俊
  • Organizer: 第一回食と環境、そして高齢化を考える研究会
  • Place of Presentation: ホテル日航金沢(石川県)
  • Year and Date: 2013-11-22
• [Presentation] 熱耐性能獲得細胞からの熱中症予防関連分子の同定 (2013)
  • Author(s): 杉本直俊、松崎健太郎、片倉賢紀、紫藤治
  • Organizer: 第52回日本生気象学会大会
  • Place of Presentation: 米子市文化ホール(鳥取県)
  • Year and Date: 2013-11-02
• [Presentation] アミロイド-β脳室内投与によるラット行動性体温調節機能の変化 (2013)
  • Author(s): 松崎健太郎、片倉賢紀、杉本直俊、宮本まゆみ、原俊子、紫藤治
  • Organizer: 第52回日本生気象学会大会
  • Place of Presentation: 米子市文化ホール(鳥取県)
  • Year and Date: 2013-11-02
• [Presentation] 高齢者の骨格筋の役割―体温調節と水分代謝の視点からの考察― (2013)
  • Author(s): 杉本直俊
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 日本教育会館・学術総合センター(東京都)
  • Year and Date: 2013-09-21
• [Presentation] 細胞から熱中症予防を考える (2013)
  • Author(s): 杉本直俊
  • Organizer: 第27回運動と体温の研究会
  • Place of Presentation: 立教大学池袋キャンパス(東京都)
  • Year and Date: 2013-09-20
• [Presentation] 培養細胞を用いた暑熱馴化の研究 (2013)
  • Author(s): 杉本直俊、松崎健太郎、紫藤治
  • Organizer: 第8回環境生理学プレコングレス
  • Place of Presentation: 東京女子医科大学・早稲田大卓連携先端生命医科学研究教育施設(TWIns)(東京都)
  • Year and Date: 2013-03-26
• [Presentation] ラット暑熱馴化形成時の唾液分泌機能変化 (2012)
  • Author(s): 松崎健太郎、杉本直俊、宮本まゆみ、原俊子、紫藤治
  • Place of Presentation: キッセイ文化ホール(長野県)
  • Year and Date: 2012-11-08
• [Presentation] 短期～長期温熱刺激が細胞のheat toleranceへ与える影響 (2012)
  • Author(s): 杉本直俊、松崎健太郎、紫藤治
  • Organizer: 第51回日本生気象学会大会
  • Place of Presentation: キッセイ文化ホール(長野県)
  • Year and Date: 2012-11-08
• [Presentation] 温熱刺激による唾液腺アクアポリンと転写因子の発現調節 (2012)
  • Author(s): 杉本直俊、田中真生、澤木俊興、藤田義正、正木康史、梅原久範
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: ウエスティン都ホテル京都(京都府)
  • Year and Date: 2012-09-07
• [Presentation] 温熱刺激による唾液腺房細胞アクアポリン5の発現調節 (2012)
  • Author(s): 杉本直俊、田中真生、澤木俊興、藤田義正、正木康史、梅原久範
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドホテル新高輪(東京都)
  • Year and Date: 2012-04-28
• [Remarks]
  • URL: http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80272954