2013 Fiscal Year Final Research Report
nalysis of non-coding RNAs transcribed from ultraconserved regions in digestive tract cancer and its diagnostic and therapeutic application
| Project/Area Number |
24659163
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
YASUI Wataru 広島大学, 医歯薬保健学研究院(医), 教授 (40191118)
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| Co-Investigator(Renkei-kenkyūsha) |
OUE Naohide 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ncRNA / 超保存領域（T-UCR) / 消化管癌 / 診断・治療展開 / 発現制御 / メチル化 |
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| Research Abstract |
Transcribed ultraconserved region (T-UCR) transcripts are a novel class of long non-coding RNAs transcribed from ultraconserved regions (UCRs). The expression analysis of T-UCR in digestive tract cancers demonstrated that, in gastric cancer, most of T-UCRs including UCR118+A and 158+A were down-regulated by methylation, whereas UCR416+A and 420+A were overexpressed. Down-regulation of miR-148 and miR-143/-145 participated in cancer invasion and morphogenesis with interaction with stromal cells and served as prognostic factor of gastric cancer patients.
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[Journal Article] High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer2014
Author(s)
Oue N, Anami K, Schetter AJ, Moehler M, Okayama H, Khan MA, Bowman ED, Mueller A, Schad A, Shimomura M, Hinoi T, Aoyagi K, Sasaki H, Okajima M, Ohdan H, Galle PR, Yasui W and Harris CC
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Journal Title
Int J Cancer
Volume: 134
Pages: 1926-1934
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[Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice2012
Author(s)
Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Sentani K, Yasui W, Rakugi H, Isaka Y and Tsukita S
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Journal Title
Gastroenterology
Volume: 142
Pages: 292-304
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[Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer2012
Author(s)
Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Oo HZ, Naito Y, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H and Yasui W
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Journal Title
Cancer Sci
Volume: 103
Pages: 1744-1750
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[Journal Article] Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-a secretion in gastric cancer
Author(s)
Oue N, Naito Y, Hayashi T, Takigahira M, Kawano-Nagatsuma A, Sentani K, Sakamoto N, Oo HZ, Uraoka N, Yanagihara K, Ochiai A, Sasaki H and Yasui W
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Journal Title
Oncogene
Volume: (In press)
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[Presentation] miR-148a, down-regulated in gastric cancer, targets MMP7 and participates in tumor invasion and poor prognosis2013
Author(s)
Sakamoto N, Naito Y, Oue N, Sentani K, Uraoka N, Oo HZ, Yanagihara K, Aoyagi K, Sasaki H and Yasui W
Organizer
10^<th> International Gastric Cancer Congress
Place of Presentation
Verona (Italy)
Year and Date
20130619-22
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