2013 Fiscal Year Final Research Report
Development of new cancer therapy using the exosomes from patients.
| Project/Area Number |
24659166
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
NAKAYA Takeo 東京医科大学, 医学部, 助教 (80512277)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Masahiko 東京医科大学, 医学部, 教授 (80251304)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | がん / エキソソーム / miRNA / CD8 T細胞 |
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| Research Abstract |
We developed the effective culture system of human CD8 T cells and effective collection methods of CD8 T cell generating exosomes. We also invented the accurate measurement system of T cell exosomes using the surface molecules of CD8 T cells. We also developed the cancer cell targeting exosomes. We investigated the tumor suppressive effects of cancer cell targeting exosomes in mice with human lung cancer cells or sarcoma cells. We observed how the miRNA including exosomes suppress the luciferase expression in luciferase expressing mice. We also investigated the methods that only hepatic cells can intake exosomes using HBV derived surface molecules.
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