Role of a 2-oxoglutarate and iron-dependent oxygenase OGFOD1 in cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659170
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: SAITO Ken 愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (70426584)
• Co-Investigator(Kenkyū-buntansha): KONDO Eisaku 新潟大学, 医学部・実験病理, 教授 (30252951)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 水酸化酵素 / がん増殖

Outline of Final Research Achievements

OGFOD1 catalyzes hydroxylation of ribosomal protein RPS23 and play a role in　the regulation of translation, as recently suggested by several groups.　However, functional role and relevance to cancer are poorly understood.　In this report, we found that OGFOD1 was primarily a nuclear protein in many　cancer cells and highly expressed in cancer tissues including esophageal　squamous cell carcinoma. Knock-down of OGFOD1 suppressed cellular proliferation through up-regulation of p21cip1 and cell-cycle arrest. Furthermore CDK inhibitor (Albocidib) affected OGFOD1 expression and cellular growth.These results support that the induction of OGFOD1 is necessary for the cell growth and cell-cycle of malignant tumor.

Free Research Field

分子生物学