2013 Fiscal Year Final Research Report
Identification of factors enabling Group A Streptococcus reside without virulence
| Project/Area Number |
24659197
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Fumito 東京医科歯科大学, 医歯学総合研究科, 准教授 (30423122)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | A群レンサ球菌 |
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| Research Abstract |
Purpose of this project is to identify factors enabling Group A Streptococcus (GAS) reside without virulence in healthy person. As results, about 80 percent of healthy adult carry this bacteria without any disease. And improvement of culture methods for GAS isolation enabled the 32 GAS isolates from 13 persons. In addition, from the transcriptome analysis using microarray, we could identify 3 genes related to GAS residence inside human cells. From phylogenetic analysis, these genes can be shared with wide range of commensal bacteria and be transferred via bacteriophage. This indicates the genes may shed light on the new mechanisms to how commensal bacteria reside with human.
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