Elucidation of Regulatory Mechanism of B1 Cells by Human IgG Natural Antibodies

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659215
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Tohoku University
• Principal Investigator: TAKAI TOSHIYUKI 東北大学, 加齢医学研究所, 教授 (20187917)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 自己抗体 / 自然免疫 / 末梢血Bリンパ球 / 制御受容体 / γグロブリン製剤

Research Abstract

We defined human peripheral blood CD20+CD27+CD43+CD70- B cells as "putative (puB1) B1 cells", and characterized them in terms of expression profiles for B cell inhibitory receptors including several isoforms of ILT/LILR and Ig production. We found a grossly similar profiles of the inhibitory receptors on puB1 cells and memory B cells, but distinctive receptor expression and Ig secretion profiles between the puB1 subset and CD43high plasmablasts.

Research Products

• [Journal Article] Role of TREM1-Dap12 in renal inflammation during obstructive nephropathy (2013)
  • Author(s): Stroo I,Tammarro A,Rampanelli E,Blank F,Butter L,Claessen N,Takai T,Colonna M,Leemans J,Florquin S,Dessing MC.
  • Journal Title: PLOS ONE Volume: (in press)
  • Peer Reviewed
• [Journal Article] Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes (2013)
  • Author(s): Montalvo V,Quigley L,Vistica BP,Boelte KC,Nugent LF,Takai T,McVicar DW,Gery I.
  • Journal Title: lmmunology Volume: 140(4) Pages: 475-482
  • DOI: 10.1111/imm.12158
  • Peer Reviewed
• [Journal Article] IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensis in a Primary Infection (2013)
  • Author(s): Matsumoto M,Sasaki Y,Yasuda K,Takai T,Muramatsu M,Yoshimoto T,Nakanishi K.
  • Journal Title: lnfect. lmmun Volume: 81 Pages: 2518-2527
  • DOI: 10.1128/IAI.00285-13
  • Peer Reviewed
• [Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis (2013)
  • Author(s): Kuroki K,Hirose K,Okabe Y,Fukunaga Y,Takahashi A,Shiroishi M,Kajikawa M,Tabata S,Nakamura S,Takai T,Koyanagi S,Ohdo S,Maenaka K.
  • Journal Title: Hum lmmunol Volume: 74 Pages: 433-438
  • DOI: 10.1016/j.humimm.2012.11.060
  • Peer Reviewed
• [Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice (2013)
  • Author(s): Kawano S,Lin Q,Amano H,Kaneko T,Nishikawa K,Tsurui H,Tada N,Nishimura H,Takai T,Shirai T,Takasaki Y,Hirose S.
  • Journal Title: Eur J lmmunol Volume: 43(3) Pages: 770-778
  • DOI: 10.1002/eji.201243057
  • Peer Reviewed
• [Journal Article] Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro (2012)
  • Author(s): Tanaka J,Hirano K,Sakamoto Y,Sugahara-Tobinai A,Endo S,Ito-Matsuoka Y,Nakano A,Inui M,Nitschke L,Takai T.
  • Journal Title: Open J. lmmunol Volume: 2(4) Pages: 149-160
  • DOI: 10.4236/oji.2012.24019
  • Peer Reviewed
• [Journal Article] Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence (2012)
  • Author(s): Nakayama M,Kurokawa K,Nakamura K,Lee BL,Sekimizu K,Kubagawa H,Hiramatsu K,Yagita H,Okumura K,Takai T,Uderhill DM,Aderem A,Ogasawara K.
  • Journal Title: J. lmmunol Volume: 189 Pages: 5903-11
  • DOI: 10.4049/jimmunol.1201940
  • Peer Reviewed
• [Journal Article] Regulation of plasmacytoid dendritic cell responses by PIR-B (2012)
  • Author(s): Mitsuhashi Y,Nakamura A,Endo S,Takeda K,Yabe-Wada T,Nukiwa T,Takai T.
  • Journal Title: Blood Volume: 120 Pages: 3256-9
  • DOI: 10.1182/blood-2012-03-419093
  • Peer Reviewed
• [Journal Article] Deletion of cognate CD8 T-cells by immature dendritic cells : a novel role for perforin,Granzyme A,TREM-1 and TLR7 (2012)
  • Author(s): Zangi L,Klionsky YZ,Yarimi L,Bacher-Lustig E,Edelshtein Y,Shezen E,Hagin D,Ito Y,Takai T,Reichi-Zeliger S,Lask A,Milstein O,Jung S,Shinder V,Reisner Y.
  • Journal Title: Blood Volume: 120(8) Pages: 1647-57
  • DOI: 10.1182/blood-2012-02-410803
  • Peer Reviewed
• [Journal Article] Runx1 deficiency in CD4^+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells (2012)
  • Author(s): Wong WF,Kohu K,Nakamura A,Ebina M,Kikuchi T,Tazawa R,Tanaka K,Kon S,Funaki T,Sugahara-Tobinai A,Looi CY,Endo S,Funayama R,Kurokawa M,Habu S,Ishii N,Fkumoto M,Nakata K,Takai T,Satake M.
  • Journal Title: J. lmmunol Volume: 188(Epub 2 May 2012) Pages: 5408-5420
  • DOI: 10.4049/jimmunol.1102991
  • Peer Reviewed
• [Presentation] Negative regulation of autoantibody production by a B cell inhibitory receptor FcγRIIB (2013)
  • Author(s): Toshiyuki Takai,Yasuyoshi Kanari,Akiko Sugahara-Tobinai
  • Organizer: NIH-Tohoku University-JSPS Symposium
  • Place of Presentation: Gonryo Hall,Sendai
  • Year and Date: 20130509-11
• [Presentation] Nogo positively regulates TLR signal pathway and inflammatory gene expression in macrophages (2013)
  • Author(s): Kimura T,Inui M,Takai T.
  • Organizer: Frontiers in Immunology and Inflammation : From Molecules to Disease
  • Place of Presentation: Tokyo
  • Year and Date: 20130212-13
• [Presentation] Regulation of TLR signaling by a reticulon family protein Nogo in macrophages (2012)
  • Author(s): Kimura T,Inui M,Takai T.
  • Organizer: The Annual Meeting of the japanese Society for Immunology
  • Place of Presentation: Kobe
  • Year and Date: 2012-12-05
• [Presentation] Negative Regulation of Autoantibody Production by a B Cell Inhibitory Receptor,FcgRIIB,Centennial of Hashimoto Disease Symposium (2012)
  • Author(s): Toshiyuki Takai
  • Organizer: International Symposium II : Autoimmune Diseases-Etiology and Therapeutics
  • Place of Presentation: ACROS Fukuoka
  • Year and Date: 2012-12-03
• [Book] 医学のあゆみ 自己免疫病とPirB(245) (2013)
  • Author(s): 乾匡範,高井俊行
  • Total Pages: 225-228
• [Book] Clin Calcium 免疫グロプリン様受容体による破骨細胞の分化制御(22(11)) (2012)
  • Author(s): 乾匡範,高井俊行
  • Total Pages: 1651-7
• [Remarks]
  • URL: http://www2.idac.tohoku.ac.jp/dep/expimmu/