Factors for the decision of mast cell subset function

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659217
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: 独立行政法人医薬基盤研究所
• Principal Investigator: JUN Kunisawa 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー (80376615)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アレルギー・ぜんそく / 免疫学 / 細胞・組織

Outline of Final Research Achievements

In this study, we analyzed the immunological function of mast cell subset using P2X7-specific antibody. We found that colonic mast cells spontaneously expressed high levels of P2X7, which played a critical role in the initiation and exacerbation of intestinal inflammation. In contrast, skin mast cells barely expressed P2X7, which was mediated by retinoic acid metabolism in skin fibroblast. We further found that disruption of the retinoic acid metabolism led to the development of skin inflammation.

Free Research Field

免疫学