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2013 Fiscal Year Final Research Report

Generation of molecular imaging pharmacology using small primate mamosets

Research Project

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Project/Area Number 24659255
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionTohoku University

Principal Investigator

YANAI KAZUHIKO  東北大学, 医学(系)研究科(研究院), 教授 (50192787)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Takeo  東北大学, 大学院医学系研究科, 助教 (70506633)
SHIBUYA Katsuhiko  東北大学, 大学院医学系研究科, 技術職員 (30596268)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords分子イメージング / マーモセット / 小動物用PET / 被ばく線量
Research Abstract

The marmoset animals are very useful for translational research. In order to keep marmosets in the PET facility and use the animals for small animal PET imaging, we investigated the regulations on animal breeding in the restricted areas of short half-life radioisotopes. We recognized that the animals administered with carbon-11 (half-life 20 min) and fluorine-18 (half-life 110 min) should be kept inside the PET centers for one week. In parallel, we performed molecular imaging studies on small animals. It is possible to estimate the radiation dosimetry in humans from distribution data obtained by small animal PET. The advantage of molecular imaging is reduction of used animals for translational research.

  • Research Products

    (36 results)

All 2014 2013 2012 2011

All Journal Article (31 results) (of which Peer Reviewed: 27 results) Presentation (4 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET2014

    • Author(s)
      Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
    • Journal Title

      Brain

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies2014

    • Author(s)
      Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Yanai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL.
    • Journal Title

      Alzheimers Res Ther

      Volume: 6(1) Pages: 11

    • DOI

      10.1186/alzrt240.eCollection

    • Peer Reviewed
  • [Journal Article] Mechanism of the histamine H3 receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice2014

    • Author(s)
      Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K.
    • Journal Title

      Neuropharmacology

      Volume: 81 Pages: 188-94

    • DOI

      10.1016/j.neuropharm.2014.02.003

    • Peer Reviewed
  • [Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease2014

    • Author(s)
      Villemagne VL, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Hodges J, Harada R, Yates P, Piguet O, Pejoska S, Dore V, Yanai K, Masters CL, Kudo Y, Rowe CC, Okamura N.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41(5) Pages: 816-26

    • DOI

      10.1007/s00259-013-2681-7

    • Peer Reviewed
  • [Journal Article] Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line2014

    • Author(s)
      Naganuma F, Yoshikawa T, Nakamura T, Iida T, Harada R, Mohsen AS, Miura Y, Yanai K.
    • Journal Title

      J Neurochem

      Volume: 129(4) Pages: 591-601

    • DOI

      10.1111/jnc.12665

    • Peer Reviewed
  • [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging2014

    • Author(s)
      Tago T, Furumoto S, Okamura N, Harada R, Ishikawa Y, Arai H, Yanai K, Iwata R, Kudo Y.
    • Journal Title

      J Label Compd Radiopharm

      Volume: 57(1) Pages: 18-24

    • DOI

      10.1002/jlcr.3133

    • Peer Reviewed
  • [Journal Article] Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis2014

    • Author(s)
      Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R,Takahashi S, Arai H, Yanai K, Kudo Y.
    • Journal Title

      Jpn J Radiol

      Volume: 32(3) Pages: 138-44

    • DOI

      10.1007/s11604-013-0276-7

    • Peer Reviewed
  • [Journal Article] Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro2014

    • Author(s)
      Guo Y, Niu K, Okazaki T, Wu H, Yoshikawa T, Ohrui T, Furukawa K, Ichinose M, Yanai K, Arai H, Huang G, Nagatomi R.
    • Journal Title

      Exp Gerontol

      Volume: 50 Pages: 1-8

    • DOI

      10.1016/j.exger.2013.11.005

    • Peer Reviewed
  • [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT : comparison with [ 11C]PIB2014

    • Author(s)
      Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41(4) Pages: 745-54

    • Peer Reviewed
  • [Journal Article] The expression and function of histamine H3 Receptor in Pancreatic 13-cells2014

    • Author(s)
      Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K.
    • Journal Title

      Br. J. Pharmacol

      Volume: 171 (1) Pages: 171-85

    • Peer Reviewed
  • [Journal Article] Use of a Benzimidazole Derivative BF-188 in Fluorescence Multispectral Imaging for Selective Visualization of Tau Protein Fibrils in the Alzheimer's Disease Brain2014

    • Author(s)
      Harada R, Okamura N, Furumoto S, Yoshikawa T, Arai H, Yanai K, Kudo Y.
    • Journal Title

      Mol Imaging Biol

      Volume: 16(1) Pages: 19-27

    • Peer Reviewed
  • [Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice2013

    • Author(s)
      Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanbe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 40(12) Pages: 848-55

    • DOI

      10.1111/1440-1681.12167

    • Peer Reviewed
  • [Journal Article] Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T, Yoshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Yamamoto T, Arai H, Iwata R, Yanai K, Kudo Y.
    • Journal Title

      J Nucl Med

      Volume: 54 (8) Pages: 1420-7

    • DOI

      10.2967/jnumed.112.117341

    • Peer Reviewed
  • [Journal Article] In vitro and in vivo characterization of 2-deoxy-2-18F-fluoro-D-mannose as a tumor-imaging agent for PET2013

    • Author(s)
      Furumoto S, Shinbo R, Iwata R, Ishikawa Y, Yanai K, Yoshioka T, Fukuda H.
    • Journal Title

      J Nucl Med

      Volume: 54(8) Pages: 1354-61

    • DOI

      10.2967/jnumed.112.113571

    • Peer Reviewed
  • [Journal Article] Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine : a positron emission tomography study in healthy volunteers2013

    • Author(s)
      Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 230 (2) Pages: 227-34

    • DOI

      10.1007/s00213-013-3146-1

    • Peer Reviewed
  • [Journal Article] Effects of Preceding Stimulation on Brain Activation in Response to Colonic Distention in Humans2013

    • Author(s)
      Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
    • Journal Title

      Psychosom Med

      Volume: 75(5) Pages: 453-62

    • DOI

      10.1097/PSY.0b013e318292668

    • Peer Reviewed
  • [Journal Article] Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro2013

    • Author(s)
      Niu K, Guo H, Guo Y, Ebihara S, Asada M, Ohrui T, Furukawa K, Ichinose M, Yanai K, Kudo Y, Arai H, Okazaki T, Nagatomi R.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: 68(12) Pages: 1482-92

    • DOI

      10.1093/gerona/glt041

    • Peer Reviewed
  • [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans2013

    • Author(s)
      Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Yanai K.
    • Journal Title

      EJNMMI Res

      Volume: 3(1) Pages: 32

    • DOI

      10.1186/2191-219X-3-32

    • Peer Reviewed
  • [Journal Article] Molecular mechanism of histamine clearance by primary human astrocytes2013

    • Author(s)
      Yoshikawa T, Naganuma F, lida T, Nakamura T, Harada R, Mohsen AS, Kasajima A, Sasano H, Yanai K.
    • Journal Title

      Glia

      Volume: 61(6) Pages: 905-16

    • DOI

      10.1002/glia.22484

    • Peer Reviewed
  • [Journal Article] A 18F-Labeled BF-227 Derivative as a Potential Radioligand for Imaging Dense Amyloid Plaques by Positron Emission Tomography2013

    • Author(s)
      Furumoto S, Okamura N, Furukawa K, Tashiro M, Ishikawa Y, Sugi K, Tomita N, Waragai M, Harada R, Tago T, Iwata R, Yanai K Arai H, Kudo Y.
    • Journal Title

      Mol Imaging Biol

      Volume: 15(4) Pages: 497-506

    • DOI

      10.1007/s11307-012-0608-5

    • Peer Reviewed
  • [Journal Article] Brain accumulation of amyloid 13 protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus2013

    • Author(s)
      Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 13(1) Pages: 215-21

    • DOI

      10.1111/j.1447-0594.2012.00880.x

    • Peer Reviewed
  • [Journal Article] ヒスタミンの生理作用 : "善玉"としてのヒスタミン2013

    • Author(s)
      飯田智光、三浦大和、長沼史登、中村正帆、吉川雄朗、谷内一彦
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: vol.11 Pages: 65-70

  • [Journal Article] 非鎮静性抗ヒスタミン薬の薬理学的特徴2013

    • Author(s)
      中村正帆、長沼史登、谷内一彦、吉川雄朗
    • Journal Title

      アレルギーの臨床

      Volume: 33 Pages: 22-26

  • [Journal Article] 「抗ヒスタミン薬はなぜ眠気を誘発するのか?」「数多く存在する抗ヒスタミン薬はどのように分類して考えればよいのか?」「抗ヒスタミン薬同士の併用は意味があるのか?」2013

    • Author(s)
      長沼史登、谷内一彦
    • Journal Title

      抗ヒスタミン薬 : 達人の処方箋メディカルレビュー社

      Pages: 301

  • [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012

    • Author(s)
      Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Yanai K, Iwata R, Mori E.
    • Journal Title

      Eur Neurol

      Volume: 68(3) Pages: 137-43

    • Peer Reviewed
  • [Journal Article] [11C]Doxepin binding to histamine H1 receptors in living human brain : reproducibility during attentive waking and circadian rhythm2012

    • Author(s)
      Shibuya K, Funaki Y, Hiraoka K, Yoshikawa T, Naganuma F, Miyake M, Watanuki S, Sato H, Tashiro M, Yanai K.
    • Journal Title

      Front Syst Neurosci

      Volume: 6 Pages: 45

    • DOI

      10.3389/fnsys.2012.00045

    • Peer Reviewed
  • [Journal Article] Roles of histamine in exercise-induced fatigue : favouring endurance and protecting against exhaustion2012

    • Author(s)
      Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T.
    • Journal Title

      Biol Pharm Bull

      Volume: 35(1) Pages: 91-7

    • Peer Reviewed
  • [Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis2012

    • Author(s)
      Furukawa K, Ikeda S, Okamura N, Tashiro M, Tomita N, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Circulation

      Volume: 125(3) Pages: 556-557

    • DOI

      10.1161/CIRCULATIONAHA.111.045237

    • Peer Reviewed
  • [Journal Article] Synthesis of [ 11 C]interleukin 8 using a cell-free translation system and L-[11C]methionine2012

    • Author(s)
      Harada R, Furumoto S, Yoshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Yanai K.
    • Journal Title

      Nucl Med Biol

      Volume: 39(1) Pages: 155-160

    • DOI

      10.1016/j.nucmedbio.2011.07.005

    • Peer Reviewed
  • [Journal Article] 日本をリードするPET橋渡し研究拠点 : 東北大学サイクロトロン・ラジオアイソトーフ。センター2012

    • Author(s)
      古本祥三、田代学、岩田錬、谷内一彦
    • Journal Title

      PET Joumal

      Volume: 18 Pages: 4-6

  • [Journal Article] Cerebral metabolic changes in men after chiropractic spinal manipulation for neck pain2011

    • Author(s)
      Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K.
    • Journal Title

      Ahern Ther Health Med

      Volume: 17(6) Pages: 12-7

    • Peer Reviewed
  • [Presentation] Antihistamine Update2013

    • Author(s)
      Kazuhiko Yanai
    • Organizer
      第63回日本アレルギー学会秋季学術大会,日本国内学会
    • Place of Presentation
      東京、日本[基調講演:英語発表]
    • Year and Date
      20131128-30
  • [Presentation] Villemagne. Molecular imaging of disease-related pathology in neurodegenerative disorders2013

    • Author(s)
      Kazuhiko Yanai
    • Organizer
      The 12^<th> meeting of the Asia Pacific Federation of Pharamacolouists (APFP),海外・国際研究会
    • Place of Presentation
      上海、中国[特別講演・招待講演:英語発表]
    • Year and Date
      20130710-12
    • Invited
  • [Presentation] 遺伝子・組織バンクと医療情報の電子化2012

    • Author(s)
      谷内一彦
    • Organizer
      第33回日本臨床薬理学会,日本国内学会
    • Place of Presentation
      沖縄、日本[基調講演]
    • Year and Date
      20121129-1201
  • [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia2012

    • Author(s)
      Kazuhiko Yanai
    • Organizer
      The 21st Korea-Japan Joint Seminar on Pharmacology,海外・国際研究会
    • Place of Presentation
      チェジュ島、韓国[特別講演・招待講演:英語発表]
    • Year and Date
      20121030-1101
    • Invited
  • [Book] ファーマーナビゲーター:抗ヒスタミン薬編2012

    • Author(s)
      宮地良樹、岡本美孝、谷内一彦(編・著)
    • Total Pages
      300
    • Publisher
      メディカルレビュー社

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Published: 2015-06-25  

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