Generation of molecular imaging pharmacology using small primate mamosets

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659255
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Tohoku University
• Principal Investigator: YANAI KAZUHIKO 東北大学, 医学(系)研究科(研究院), 教授 (50192787)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Takeo 東北大学, 大学院医学系研究科, 助教 (70506633) ; SHIBUYA Katsuhiko 東北大学, 大学院医学系研究科, 技術職員 (30596268)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 分子イメージング / マーモセット / 小動物用PET / 被ばく線量

Research Abstract

The marmoset animals are very useful for translational research. In order to keep marmosets in the PET facility and use the animals for small animal PET imaging, we investigated the regulations on animal breeding in the restricted areas of short half-life radioisotopes. We recognized that the animals administered with carbon-11 (half-life 20 min) and fluorine-18 (half-life 110 min) should be kept inside the PET centers for one week. In parallel, we performed molecular imaging studies on small animals. It is possible to estimate the radiation dosimetry in humans from distribution data obtained by small animal PET. The advantage of molecular imaging is reduction of used animals for translational research.

Research Products

• [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET (2014)
  • Author(s): Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
  • Journal Title: Brain Volume: (in press)
  • Peer Reviewed
• [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies (2014)
  • Author(s): Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Yanai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL.
  • Journal Title: Alzheimers Res Ther Volume: 6(1) Pages: 11
  • DOI: 10.1186/alzrt240.eCollection
  • Peer Reviewed
• [Journal Article] Mechanism of the histamine H3 receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice (2014)
  • Author(s): Mohsen A, Yoshikawa T, Miura Y, Nakamura T, Naganuma F, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K.
  • Journal Title: Neuropharmacology Volume: 81 Pages: 188-94
  • DOI: 10.1016/j.neuropharm.2014.02.003
  • Peer Reviewed
• [Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease (2014)
  • Author(s): Villemagne VL, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Hodges J, Harada R, Yates P, Piguet O, Pejoska S, Dore V, Yanai K, Masters CL, Kudo Y, Rowe CC, Okamura N.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41(5) Pages: 816-26
  • DOI: 10.1007/s00259-013-2681-7
  • Peer Reviewed
• [Journal Article] Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line (2014)
  • Author(s): Naganuma F, Yoshikawa T, Nakamura T, Iida T, Harada R, Mohsen AS, Miura Y, Yanai K.
  • Journal Title: J Neurochem Volume: 129(4) Pages: 591-601
  • DOI: 10.1111/jnc.12665
  • Peer Reviewed
• [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging (2014)
  • Author(s): Tago T, Furumoto S, Okamura N, Harada R, Ishikawa Y, Arai H, Yanai K, Iwata R, Kudo Y.
  • Journal Title: J Label Compd Radiopharm Volume: 57(1) Pages: 18-24
  • DOI: 10.1002/jlcr.3133
  • Peer Reviewed
• [Journal Article] Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis (2014)
  • Author(s): Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R,Takahashi S, Arai H, Yanai K, Kudo Y.
  • Journal Title: Jpn J Radiol Volume: 32(3) Pages: 138-44
  • DOI: 10.1007/s11604-013-0276-7
  • Peer Reviewed
• [Journal Article] Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro (2014)
  • Author(s): Guo Y, Niu K, Okazaki T, Wu H, Yoshikawa T, Ohrui T, Furukawa K, Ichinose M, Yanai K, Arai H, Huang G, Nagatomi R.
  • Journal Title: Exp Gerontol Volume: 50 Pages: 1-8
  • DOI: 10.1016/j.exger.2013.11.005
  • Peer Reviewed
• [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT : comparison with [ 11C]PIB (2014)
  • Author(s): Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41(4) Pages: 745-54
  • Peer Reviewed
• [Journal Article] The expression and function of histamine H3 Receptor in Pancreatic 13-cells (2014)
  • Author(s): Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K.
  • Journal Title: Br. J. Pharmacol Volume: 171 (1) Pages: 171-85
  • Peer Reviewed
• [Journal Article] Use of a Benzimidazole Derivative BF-188 in Fluorescence Multispectral Imaging for Selective Visualization of Tau Protein Fibrils in the Alzheimer's Disease Brain (2014)
  • Author(s): Harada R, Okamura N, Furumoto S, Yoshikawa T, Arai H, Yanai K, Kudo Y.
  • Journal Title: Mol Imaging Biol Volume: 16(1) Pages: 19-27
  • Peer Reviewed
• [Journal Article] Roles played by histamine in strenuous or prolonged masseter muscle activity in mice (2013)
  • Author(s): Yoneda H, Niijima-Yaoita F, Tsuchiya M, Kumamoto H, Watanbe M, Ohtsu H, Yanai K, Tadano T, Sasaki K, Sugawara S, Endo Y.
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 40(12) Pages: 848-55
  • DOI: 10.1111/1440-1681.12167
  • Peer Reviewed
• [Journal Article] Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Tago T, Yoshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Yamamoto T, Arai H, Iwata R, Yanai K, Kudo Y.
  • Journal Title: J Nucl Med Volume: 54 (8) Pages: 1420-7
  • DOI: 10.2967/jnumed.112.117341
  • Peer Reviewed
• [Journal Article] In vitro and in vivo characterization of 2-deoxy-2-18F-fluoro-D-mannose as a tumor-imaging agent for PET (2013)
  • Author(s): Furumoto S, Shinbo R, Iwata R, Ishikawa Y, Yanai K, Yoshioka T, Fukuda H.
  • Journal Title: J Nucl Med Volume: 54(8) Pages: 1354-61
  • DOI: 10.2967/jnumed.112.113571
  • Peer Reviewed
• [Journal Article] Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine : a positron emission tomography study in healthy volunteers (2013)
  • Author(s): Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
  • Journal Title: Psychopharmacology (Berl) Volume: 230 (2) Pages: 227-34
  • DOI: 10.1007/s00213-013-3146-1
  • Peer Reviewed
• [Journal Article] Effects of Preceding Stimulation on Brain Activation in Response to Colonic Distention in Humans (2013)
  • Author(s): Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
  • Journal Title: Psychosom Med Volume: 75(5) Pages: 453-62
  • DOI: 10.1097/PSY.0b013e318292668
  • Peer Reviewed
• [Journal Article] Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro (2013)
  • Author(s): Niu K, Guo H, Guo Y, Ebihara S, Asada M, Ohrui T, Furukawa K, Ichinose M, Yanai K, Kudo Y, Arai H, Okazaki T, Nagatomi R.
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 68(12) Pages: 1482-92
  • DOI: 10.1093/gerona/glt041
  • Peer Reviewed
• [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans (2013)
  • Author(s): Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Yanai K.
  • Journal Title: EJNMMI Res Volume: 3(1) Pages: 32
  • DOI: 10.1186/2191-219X-3-32
  • Peer Reviewed
• [Journal Article] Molecular mechanism of histamine clearance by primary human astrocytes (2013)
  • Author(s): Yoshikawa T, Naganuma F, lida T, Nakamura T, Harada R, Mohsen AS, Kasajima A, Sasano H, Yanai K.
  • Journal Title: Glia Volume: 61(6) Pages: 905-16
  • DOI: 10.1002/glia.22484
  • Peer Reviewed
• [Journal Article] A 18F-Labeled BF-227 Derivative as a Potential Radioligand for Imaging Dense Amyloid Plaques by Positron Emission Tomography (2013)
  • Author(s): Furumoto S, Okamura N, Furukawa K, Tashiro M, Ishikawa Y, Sugi K, Tomita N, Waragai M, Harada R, Tago T, Iwata R, Yanai K Arai H, Kudo Y.
  • Journal Title: Mol Imaging Biol Volume: 15(4) Pages: 497-506
  • DOI: 10.1007/s11307-012-0608-5
  • Peer Reviewed
• [Journal Article] Brain accumulation of amyloid 13 protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus (2013)
  • Author(s): Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
  • Journal Title: Geriatr Gerontol Int Volume: 13(1) Pages: 215-21
  • DOI: 10.1111/j.1447-0594.2012.00880.x
  • Peer Reviewed
• [Journal Article] ヒスタミンの生理作用 : "善玉"としてのヒスタミン (2013)
  • Author(s): 飯田智光、三浦大和、長沼史登、中村正帆、吉川雄朗、谷内一彦
  • Journal Title: 皮膚アレルギーフロンティア Volume: vol.11 Pages: 65-70
• [Journal Article] 非鎮静性抗ヒスタミン薬の薬理学的特徴 (2013)
  • Author(s): 中村正帆、長沼史登、谷内一彦、吉川雄朗
  • Journal Title: アレルギーの臨床 Volume: 33 Pages: 22-26
• [Journal Article] 「抗ヒスタミン薬はなぜ眠気を誘発するのか?」「数多く存在する抗ヒスタミン薬はどのように分類して考えればよいのか?」「抗ヒスタミン薬同士の併用は意味があるのか?」 (2013)
  • Author(s): 長沼史登、谷内一彦
  • Journal Title: 抗ヒスタミン薬 : 達人の処方箋メディカルレビュー社 Pages: 301
• [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia (2012)
  • Author(s): Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Yanai K, Iwata R, Mori E.
  • Journal Title: Eur Neurol Volume: 68(3) Pages: 137-43
  • Peer Reviewed
• [Journal Article] [11C]Doxepin binding to histamine H1 receptors in living human brain : reproducibility during attentive waking and circadian rhythm (2012)
  • Author(s): Shibuya K, Funaki Y, Hiraoka K, Yoshikawa T, Naganuma F, Miyake M, Watanuki S, Sato H, Tashiro M, Yanai K.
  • Journal Title: Front Syst Neurosci Volume: 6 Pages: 45
  • DOI: 10.3389/fnsys.2012.00045
  • Peer Reviewed
• [Journal Article] Roles of histamine in exercise-induced fatigue : favouring endurance and protecting against exhaustion (2012)
  • Author(s): Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T.
  • Journal Title: Biol Pharm Bull Volume: 35(1) Pages: 91-7
  • Peer Reviewed
• [Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis (2012)
  • Author(s): Furukawa K, Ikeda S, Okamura N, Tashiro M, Tomita N, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H.
  • Journal Title: Circulation Volume: 125(3) Pages: 556-557
  • DOI: 10.1161/CIRCULATIONAHA.111.045237
  • Peer Reviewed
• [Journal Article] Synthesis of [ 11 C]interleukin 8 using a cell-free translation system and L-[11C]methionine (2012)
  • Author(s): Harada R, Furumoto S, Yoshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Yanai K.
  • Journal Title: Nucl Med Biol Volume: 39(1) Pages: 155-160
  • DOI: 10.1016/j.nucmedbio.2011.07.005
  • Peer Reviewed
• [Journal Article] 日本をリードするPET橋渡し研究拠点 : 東北大学サイクロトロン・ラジオアイソトーフ。センター (2012)
  • Author(s): 古本祥三、田代学、岩田錬、谷内一彦
  • Journal Title: PET Joumal Volume: 18 Pages: 4-6
• [Journal Article] Cerebral metabolic changes in men after chiropractic spinal manipulation for neck pain (2011)
  • Author(s): Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K.
  • Journal Title: Ahern Ther Health Med Volume: 17(6) Pages: 12-7
  • Peer Reviewed
• [Presentation] Antihistamine Update (2013)
  • Author(s): Kazuhiko Yanai
  • Organizer: 第63回日本アレルギー学会秋季学術大会,日本国内学会
  • Place of Presentation: 東京、日本[基調講演:英語発表]
  • Year and Date: 20131128-30
• [Presentation] Villemagne. Molecular imaging of disease-related pathology in neurodegenerative disorders (2013)
  • Author(s): Kazuhiko Yanai
  • Organizer: The 12^<th> meeting of the Asia Pacific Federation of Pharamacolouists (APFP),海外・国際研究会
  • Place of Presentation: 上海、中国[特別講演・招待講演:英語発表]
  • Year and Date: 20130710-12
  • Invited
• [Presentation] 遺伝子・組織バンクと医療情報の電子化 (2012)
  • Author(s): 谷内一彦
  • Organizer: 第33回日本臨床薬理学会,日本国内学会
  • Place of Presentation: 沖縄、日本[基調講演]
  • Year and Date: 20121129-1201
• [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia (2012)
  • Author(s): Kazuhiko Yanai
  • Organizer: The 21st Korea-Japan Joint Seminar on Pharmacology,海外・国際研究会
  • Place of Presentation: チェジュ島、韓国[特別講演・招待講演:英語発表]
  • Year and Date: 20121030-1101
  • Invited
• [Book] ファーマーナビゲーター:抗ヒスタミン薬編 (2012)
  • Author(s): 宮地良樹、岡本美孝、谷内一彦(編・著)
  • Total Pages: 300
  • Publisher: メディカルレビュー社