Chromosomal instability and Clinico-pathologial feature in Lung Cancer

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659267
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: The University of Tokyo
• Principal Investigator: TAKAI Daiya 東京大学, 医学部附属病院, 講師 (90361493)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 肺がん

Research Abstract

We changed study design because several genes showed no mutation included in original study design. Thus we analyzed 3' untranslated region (3'UTR) of mRNA that was revealed to be shorten in cancers. 3'UTR is important in post transcriptional regulation of genes and it is known as a target of microRNAs. We firstly analyzed lung cancer specifically shorten mRNA using computational analyses of opened microarray data. We choose ten genes which are shortened in lung cancer and evaluated their status in clinical specimens using with quantitative RT-PCR. We revealed that increase of gene number of 3'UTR shortening is strongly associated post surgical recurrence in lung cancer.

Research Products

• [Journal Article] Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model (2013)
  • Author(s): Yamauchi H, Motomura N, Chung UI, Sata M, Takai D, Saito A, Ono M, Takamoto S.
  • Journal Title: J Thorac Car diovasc Surg Volume: 145(2) Pages: 522-530
• [Journal Article] Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer (2013)
  • Author(s): Takahara N, Nakai Y, Isayama H, Sasaki T, Satoh Y, Takai D, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Mohri D, Kawakubo K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tada M, Yatomi Y, Koike K.
  • Journal Title: Cancer Chemother Pharmacol Volume: 71(1) Pages: 85-92
• [Journal Article] High-grade lung adenocarcinoma with fetal-lung-like morphology–Clinicopathological, immunohistochemical, and molecular analyses of 17 cases (2013)
  • Author(s): Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, Asamura H, Nakajima J, Takai D, Mori M, Oka T, Tamaru J, Itoyama S, Furuta K, Fukayama M, Tsuda H.
  • Journal Title: Amer ican J of Sur g. Pathology Volume: 37(6) Pages: 924-932
• [Journal Article] FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer (2013)
  • Author(s): Kawakami M, Morita S, Sunohara M, Amano Y, Ishikawa R, Watanabe K, Hamano E, Ohishi N, Nakajima J, Yatomi Y, Nagase T, Fukayama M, Takai D.
  • Journal Title: Int J Clin Exp Pathol Volume: 6(4) Pages: 598-612
• [Journal Article] A pilot study of salvage irinotecan monotherapy for advanced biliary tract cancer (2013)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Takahara N, Satoh Y, Takai D, Kogure H, Yamamoto N, Hirano K, Tada M, Yatomi Y, Koike K.
  • Journal Title: Anticancer Res Volume: 33(6) Pages: 2619-2622
• [Journal Article] Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Epidermal Growth Factor Receptor Mutation in a Female Patient Who Never Smoked (2013)
  • Author(s): Yoshida Y, Ota S, Murakawa T, Takai D, Nakajima J.
  • Journal Title: Ann Thorac Cardiovasc Sur g Volume: (Epub ahead)
• [Journal Article] Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer (2013)
  • Author(s): Kawakami M, Ishikawa R, Amano Y, Sunohara M, Watanabe K, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D.
  • Journal Title: Cancer Sci Volume: 104(11) Pages: 1447-1454
• [Journal Article] Successful Treatment of Mediastinal Unicentric Castleman's Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization (2013)
  • Author(s): Amano Y, Takai D, Ohishi N, Shinozaki-Ushiku A, Fukayama M, Akahane M, Nakajima J, Nagase T.
  • Journal Title: Case Rep Med Pages: 354507
• [Journal Article] Disruption of the expression and function of microRNAs in lung cancer as a result of epigenetic changes (2013)
  • Author(s): Watanabe K & Takai D.
  • Journal Title: Frontier s in Genetics Volume: 4 Pages: 275
• [Journal Article] Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer (2012)
  • Author(s): Watanabe K, Emoto N, Hamano E, Sunohara M, Kawakami M, Kage H, Kitano K, Nakajima J, Goto A, Fukayama M, Nagase T, Yatomi Y, Ohishi N, Takai D.
  • Journal Title: Int J Cancer Volume: 130(11) Pages: 2580-2590
• [Journal Article] Pulmonary Venous Invasion, Determined by Chest Computed Tomographic Scan, as a Potential Early Indicator of Zygomycosis Infection : A Case Series (2012)
  • Author(s): Kitagawa H, Watanabe K, Kage H, Inoh S, Goto A, Fukayama M, Nagase T, Ohishi N, Takai D.
  • Journal Title: J Thorac Imaging Volume: 27(4) Pages: W97-99
• [Journal Article] Analysis for the combination expression of CK20, FABP1 and MUC2 is sensitive for the prediction of peritoneal recurrence in gastric cancer (2012)
  • Author(s): Satoh Y, Mori K, Kitano K, Kitayama J, Yokota H, Sasaki H, Uozaki H, Fukayama M, Seto Y, Nagawa H, Yatomi Y, Takai D.
  • Journal Title: J pn J Clin Oncol Volume: 42(2) Pages: 148-152
• [Presentation] Loss of PABPN1 and alternative polyadenylation yield poor prognosis in non-small cell lung cancer (2014)
  • Author(s): Ichinose J, Watanabe K, Sano A, Nagase T, Nakajima J, Fukayama M, Yatomi Y, Ohishi N, Takai D.
  • Organizer: AACR-IASLC Joint Conference on The Molecular Origins of Lung Cancer
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20140106-09
• [Presentation] Can lung cancer with overexpression of RET-proto oncogene be a good candidate for vandetanib treatment? (2014)
  • Author(s): Sunohara M, Morita S, Kawakami M, Watanabe K, Kage H, Amano Y, Ishikawa R, Fukayama M, Nagase T, Ohishi N, Takai D.
  • Organizer: AACR-IASLC Joint Conference on The Molecular Origins of Lung Cancer
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20140106-09
• [Presentation] Histone methylation-mediated silencing of mir-139 enhances an aggressive phenotype of non-small cell lung cancer (2014)
  • Author(s): Watanabe K, Sunohara M, Amano Y, Ishikawa R, Ichinose J, Nakajima J, Fukayama M, Yatomi Y, Nagase T, Ohishi N, Takai D.
  • Organizer: AACR-IASLC Joint Conference on The Molecular Origins of Lung Cancer
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20140106-09
• [Presentation] Vandetanib Can Overcome the Acquired Resistance to Gefitinib Due to RET Overexpression in Lung Cancer (2012)
  • Author(s): Sunohara M, Kawakami K, Watanabe K, Morita S, Kage H, Amano Y , Fukayama M, Nagase T, N. Ohishi N, Takai D.
  • Organizer: The 24th EORTC-NCI-AACR Symposium on'Molecular Targets and Cancer Therapeutics'
  • Place of Presentation: Dublin, Island
  • Year and Date: 20121106-09
• [Presentation] Identification of FER as a New Molecular Target in Non-small Cell Lung Cancer (2012)
  • Author(s): Kawakami M, Sunohara M, Amano Y, Ishikawa R, Watanabe K, Hamano E, Ohishi N, Nagase T, Yatomi Y, Takai D.
  • Organizer: The 24th EORTC-NCI- AACR Symposium on'Molecular Targets and Cancer Therapeutics'
  • Place of Presentation: Dublin, Island
  • Year and Date: 20121106-09
• [Remarks]
  • URL: http://kokyuki.umin.jp/305.html