2013 Fiscal Year Final Research Report
RB1CC1 and p62/SQSTM1 abnormalities in human carcinogenesis, and their utilities on clinical application
| Project/Area Number |
24659272
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHANO Tokuhiro 滋賀医科大学, 医学部, 准教授 (40346028)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 腫瘍検査 / p62/SQSTM1 / RB1CC1 / Nrf2 / GSH |
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| Research Abstract |
Staining of p62/SQSTM1 and RB1CC1 was scored by using a tissue microarray of lung cancers. RB1CC1 is expressed only in the cytoplasm of lung cancers, suggesting poor prognosis of lung cancers. p62/SQSTM1 accumulation was further associated with the worse survival, especially the worst in the cases with both expressions of p62/SQSTM1 and RB1CC1. p62/SQSTM1 could become a biomarker of worse prognosis in lung cancer cases.
In oral squamous cell carcinomas, p62/SQSTM1 contributed to induce glutathione in oral carcinoma cells, and to cause a resistance to radiation therapy. Clinico-pathological detection of p62/SQSTM1 accumulation could predict poor prognosis, and could be a new biomarker in the cases of oral squamous cell carcinoma.
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