2013 Fiscal Year Final Research Report
Acridine orange photodynamic antimicrobial chemotherapy for drug resistant bacterias
| Project/Area Number |
24659284
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TSUNODA Ryu 日本医科大学, 医学部, 助教 (10386188)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Shinro 日本医科大学, 医学研究科, 教授 (10226730)
TAKAHASI Kenji 日本医科大学, 医学研究科, 准教授 (30347447)
NOROSE Yoshihiko 日本医科大学, 医学研究科, 助教 (10097024)
NEI Takahito 日本医科大学, 医学研究科, 助教 (30597670)
KAWAJI Hidemi 日本医科大学, 医学研究科, 講師 (90277517)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 光線力学療法 / アクリジンオレンジ / 感染症 |
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| Research Abstract |
The effect of acridine orange photodynamic antimicrobial chemotherapy for drug resistant bacterias was examined.
Growth was significantly suppressed at 50 microgram/ml of acridine orange solution in Acinetobacter, vancomycin-resistant enterococci, enterococci, methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, the growth rate was 4%, 17%, 18%, 7%, and 15% respectively.
It was not revealed mechanism of growth inhibition of bacteria by the present method. Since the relatively strong growth inhibitory effect was observed against methicillin-resistant Staphylococcus aureus ,I was considered that acridine orange photodynamic antimicrobial chemotherapy was also possible clinical application in infection of bone and soft tissue.
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