2013 Fiscal Year Final Research Report
A metabolomics study of children with neurodevelopmental problems due to dioxin exposure
| Project/Area Number |
24659306
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIJO Muneko 金沢医科大学, 医学部, 准教授 (40198461)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156)
NAKAMURA Kousi 金沢医科大学, 医学部, 准教授 (80422898)
SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ダイオキシン / メタボロミクス / 尿検査 / 脳神経発達 / 自閉症スペクトラム障害 / 早期指標 / ベトナム |
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| Research Abstract |
In a hot spot of dioxin contamination in Vietnam, we examined social emotional behaviors by autism spectrum rating scale (ASRS) of 3-year-old children and found that the high TCDD exposed group showed higher ASRS scores as compared with the lower exposed groups, suggesting autistic traits. Then, we analyzed urinary metabolomes of the high TCDD group and age and gender matched low exposure groups and detected candidate compound to discriminate these high and low TCDD groups. Urinary histidine and tryptophan were selected for good negative markers and significant decreased levels of these amino acids were observed in the high TCDD group. However, no significant correlation was observed between dioxin levels in breast milk and urinary levels of histidine and tryptophan in 68 6-month-old infants living in another hot spot in Vietnam. They might be too young to detect alteration of urinary amino acids. We need to follow-up them for longer time and collect more number of urine specimens.
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[Presentation] Perinatal dioxin exposure and neurodevelopment of children aged 3 years–A follow up study in Vietnam2013
Author(s)
Tai PT, Nishijo M, Anh NTN, Maruzeni S, Nakagawa H, Luong HV, Anh TH, Nhat TV, Thanh TT, Phuong PT, Son LK, Morikawa Y, Kido T, Nishijo H.
Organizer
33rd international Symposium on Halogenated Persistent Organic pollutants
Place of Presentation
大邱(韓国)
Year and Date
2013-08-29
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[Presentation] Dioxin concentration in breast milk of primipara mothers in Bien Hoa, a hot spot area in Vietnam-A preliminary study in 2012-2013
Author(s)
Nishijo M, Nghi TN, Manh HD, Tai PT, Anh NTN, Vu PHA, Nguyen NT, Hung NX, Hoan HM, Hai HC, Nishijo H, Hai-Anh T, Luong HV, Kido T, Okamoto R, Son LK, Nakagawa H.
Organizer
33rd international Symposium on Halogenated Persistent Organic pollutants
Place of Presentation
大邱(韓国)
Year and Date
2013-08-27
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[Presentation] ダイオキシン環境曝露の出生児の脳神経発達に与える影響 : ベトナムにおける小児コホート3年間の追跡2013
Author(s)
西条旨子、Pham The Tai, Nguyen Thi Nguyet Anh, Tran Ngoc Nghi,丸銭笑子,中川秀昭,森河裕子,岡本理恵,城戸照彦, Hoang Van Luong, Tran Hai Anh, Phan Thanh Phuong,西条寿夫
Organizer
第23回日本疫学会学術総会
Place of Presentation
吹田市
Year and Date
2013-01-26
