Impact of susceptible genes and stresss on endophenotype of irritable bowel syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659344
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: FUKUDO Shin 東北大学, 医学(系)研究科(研究院), 教授 (80199249)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳腸相関 / 過敏性腸症候群 / 遺伝子 / ストレス / 炎症 / 消化管運動 / 消化管知覚 / 神経伝達物質

Outline of Final Research Achievements

Patients with irritable bowel syndrome (IBS) are characterized with exaggerated response to psychosocial stressors. We previously reported exaggerated colonic motility in IBS patients in response to administration of corticotropin-releasing hormone (CRH) which is one of key mediators of stress response. This study aimed to test the hypothesis that IBS and its phenotypes are associated with candidate genotypes and stress. Several candidate genes including CRH and allied molecules with association to IBS and its phenotypes were analyzed. As results, CRH receptor 1 genotypes and its haplotype were associated with IBS phenotype and bowel pattern. These results suggest that psychosocial stress may affect on the phenotype and endophenotypes of IBS.

Free Research Field

心身医学