A novel ultrasound imaging for pancreatic cancer using tumor directed-contrast media

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659372
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: KATO Junji 札幌医科大学, 医学部, 教授 (20244345)
• Co-Investigator(Kenkyū-buntansha): TAKIMOTO Rishu 札幌医科大学, 医学部, 准教授 (10336399) ; HAYASHI Tsuyoshi 札幌医科大学, 医学部, 講師 (60381258) ; ISHIWATARI Hirotoshi 札幌医科大学, 医学部, 助教 (90468083)
• Project Period (FY): 2012 – 2013
• Keywords: 超音波造影剤 / 膵癌

Research Abstract

Patients with pancreatic ductal carcinoma (PDAC) are dismal prognosis due to absence of effective modality to diagnose at early stage. We have recently developed a novel targeting nanoparticle for PDAC using fucose receptor mediated-endocytosis (PLoS ONE, 2012). Our nanoparticles carrying anti-cancer drugs could specifically delivered agents to PDAC cells and suppressed tumor growth. We then utilized this strategy for diagnosing PDAC as a novel ultrasound imaging. We encapsulated perfulbutane (PFB) into our nanoparticles and succeeded to image PDAC as a tumor in xenografted rat model using ultrasound sonography.

Research Products

• [Journal Article] Fucosylated TGF-β receptors transduces a signal for epithelialmesenchymal transition in colorectal cancer cells. (2014)
  • Author(s): Hirakawa M, Takimoto R, Hayashi T, Kobune M, Kato J, et al.
  • Journal Title: Br J Cancer Volume: 110 Pages: 156-63
  • Peer Reviewed
• [Journal Article] A novel strategy inducing autophagic cell death in Burkitt's lymphoma cells with anti-CD19-targeted liposomal rapamycin. (2014)
  • Author(s): Ono K, Hayashi T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kato J, et al.
  • Journal Title: Blood Cancer J Volume: 7 Pages: 4e180
  • Peer Reviewed
• [Journal Article] A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer : nucleotide excision repair (NER) as potential chemoresistance marker. (2013)
  • Author(s): Hirakawa M, Hayashi T , Sato T ,Miyanishi K,Takimoto R,Kobune M,Hirata K,Kato J, et al.
  • Journal Title: Cancer Chemother Pharmacol Volume: 71 Pages: 789-797
  • Peer Reviewed
• [Journal Article] Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. (2013)
  • Author(s): Tanaka S, Hayashi T,Sato T,Sato Y,Takimoto R,Kato J, et al.
  • Journal Title: J Gastroenterol Volume: 28 Pages: 656-663
  • Peer Reviewed
• [Journal Article] A case of idiopathic encapsulating peritoneal sclerosis with intractable ileus successfully treated by surgery and steroid therapy. (2013)
  • Author(s): Ikeda Y, Hayashi T,Sato T,Miyanishi K,Takimoto R,Kohune M,Nobuoka T,Noguchi H,Oi M,Honma H,Hirata K,Hasegawa T,Kato J, et al.
  • Journal Title: Clin J Gastroenterol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Rapid on-site evaluation by endosonographer during endoscopic ultrasound-guided fine needle aspiration for pancreatic solid masses. (2013)
  • Author(s): Hayashi T, Ishiwatari H, Takimoto R, Mitsuhashi T, Asanuma H, Ogino J, Hasegawa T, Sonoda T, Kato J, et al.
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Pages: 656-663
  • Peer Reviewed
• [Journal Article] Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes. (2013)
  • Author(s): Ishiwatari H, Takimoto R, Kato J, Niitsu Y, et al.
  • Journal Title: Gut Volume: 62 Pages: 1328-39
  • Peer Reviewed
• [Journal Article] Diagnostic validity of CT gastrography versus gastroscopy for primary lesions in gastric cancer : evaluating the response to chemotherapy, a retrospective analysis. (2013)
  • Author(s): Takahashi S, Takimoto R, Kobune M, Kato J, et al.
  • Journal Title: Gastric Cancer Volume: 16 Pages: 543-548
  • Peer Reviewed
• [Journal Article] A retrospective clinical analysis of Japanese patients with peripheral T-cell lymphoma not otherwise specified : Hokkaido Hematology Study Group. (2013)
  • Author(s): Torimoto Y, Takimoto R, Tanaka J, Yamamoto S, Kohgo Y, Fukuhara T, et al.
  • Journal Title: Int J Hematol Volume: 98 Pages: 171-8
  • Peer Reviewed
• [Journal Article] Epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies. (2012)
  • Author(s): Kurosawa M, Takimoto R, Torimoto Y, Mori A, Takahashi T, Iizuka S, Ishida T, Kobayashi R, Oda T, Sakai H, Yamamoto S, Takahashi F, Fukuhara T, et al.
  • Journal Title: Int J Hematol Volume: 96 Pages: 748-57
  • Peer Reviewed
• [Presentation] Targeting Pancreatic Cancer Stem Like Cells Using a Nanoparticle Modified by L-Fucose. (2013)
  • Author(s): Takimoto R,Yoshida M,Murase K,Sato Y,Hirakawa M,Tamura F,Sato T,Osuga T,Miyanishi K,Takada K,Hayash T,Kobune M,Kato J.
  • Organizer: The American Association for the Study of Liver Diseases-Digestive Disease Week (DDW 2013)
  • Place of Presentation: Orlando, U.S.A.
  • Year and Date: 20130519-21
• [Presentation] Iron chelation therapy improves oxidative DNA damage in hematopoietic cells derived from transfusion-dependent myelodysplastic syndrome. (2013)
  • Author(s): Kobune M,Kikuchi S,Iyama S,Takada K,Murase K,Ono K,Horiguchi H,Kamihara Y,Hayashi T,Sato T,Miyanishi K,Sato Y,Takimoto R,Kato J .
  • Organizer: Fifth Congress of the International BioIron Society (IBIS) Biennial World Meeting (BioIron2013)
  • Place of Presentation: London, UK.
  • Year and Date: 20130414-18
• [Presentation] Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. (2013)
  • Author(s): Takimoto R, Yoshida M, Sato Y, Hirakawa M, Tamura F, Sato T, Iyama S, Osuga T, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
  • Organizer: Ninth AACR-Japanese Cancer Association Joint Conference : Breakthroughs in Basic and Translational Cancer Research
  • Place of Presentation: Maui,USA.
  • Year and Date: 20130221-25