Development of novel therapeutic strategy for atherosclerotic vascular diseases via the activation of natural killer T cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 24659379
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: TSUTSUI Hiroyuki 北海道大学, 大学院・医学研究科, 教授 (70264017)
• Co-Investigator(Kenkyū-buntansha): KINUGAWA Shintaro 北海道大学, 大学院・医学研究科, 講師 (60399871) ; ISHIMORI Naoki 北海道大学, 大学院・医学研究科, 助教 (70399848)
• Project Period (FY): 2012
• Keywords: 動脈硬化 / 炎症性サイトカイン / ナチュラルキラーT 細胞 / Th1/Th2 バランス / 樹状細胞

Research Abstract

The development and progression of atherosclerosis involves complex inflammatory processes between hematocytes and vascular tissues. Natural killer T (NKT) cells, a unique subset of T lymphocytes that recognize glycolipid antigens and secrete a large amount of TH1/TH2 cytokines, play a crucial role in regulating tissue inflammation. The present study demonstrated that inflammatory process regulated via NKT cells is involved in atherosclerotic lesions and NKT cells may be the novel therapeutic targets in atherosclerotic vascular diseases.

Research Products

• [Journal Article] Type II NKT cells stimulatediet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance (2012)
  • Author(s): Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Eshima K, Nakayama T, Taniguchi M, Hirata N, Ishimori N, Tsutsui H, Onoe K, Iwabuchi K
  • Journal Title: PLoS ONE Volume: 7(2) Pages: e30568
  • DOI: DOI:10.1371
  • Peer Reviewed
• [Journal Article] Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: report from the Hokkaido acute myocardial infarction registry (2012)
  • Author(s): Satoh H, Ishimori N, Sakakibara M,Yamada S, Kawashima N, Urasawa K, FujiiS, Tsutsui H
  • Journal Title: HypertensRes Volume: 35(4) Pages: 463-469
  • DOI: DOI:10.1038
  • Peer Reviewed
• [Journal Article] Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice (2012)
  • Author(s): Sobirin MA, Kinugawa S, Takahashi M, Fukushima A, Homma T, Ono T, Hirabayashi K, Suga T, Azalia P, Takada S, Taniguchi M, Nakayama T, Ishimori N,Iwabuchi K, Tsutsui H
  • Journal Title: Circ Res Volume: 111(8) Pages: 1037-47
  • DOI: DOI:10.1161
  • Peer Reviewed
• [Journal Article] Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation inapolipoprotein E-deficient mice (2012)
  • Author(s): Danzaki K, Matsui Y, Ikesue M, Ohta D, Ito K, Kanayama M, Kurotaki D, Morimoto J, Iwakura Y, Yagita H, Tsutsui H, Uede T
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32(2) Pages: 273-80
  • DOI: DOI:10.1161
  • Peer Reviewed
• [Presentation] Invariant natural killer T cells are involved in the development ofexperimental abdominal aortic aneurysm and dissection in apolipoprotein-E deficient mice (2012)
  • Author(s): Ishimori N, Tokuhara S, Nozawa A, Saito A, Tsutsui H
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: International Congress Center Munich, Germany
  • Year and Date: 20120000
• [Presentation] Activation of natural killer T cells ameliorates the development of angiotensin II-mediated abdominal aortic aneurysm formation in obese ob/ob mice (2012)
  • Author(s): Saito A, Ishimori N, Tokuhara S, Nozawa A,Nishikawa M, Tsutsui H
  • Organizer: American Heart Association Scientific Sessions 2012, Los Angeles
  • Place of Presentation: Orange County Convention Center, America
  • Year and Date: 20120000
• [Book] 知のフロンティア北海道大学の研究者は、いま第2号 (2012)
  • Author(s): 筒井裕之
  • Total Pages: 68-69
  • Publisher: 北海道大学アドミッションセンター