2013 Fiscal Year Final Research Report
Elucidation of cardiovascular pathologies by regulating the processing of the peptide
| Project/Area Number |
24659383
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUZUKI Toru 東京大学, 医学部附属病院, 准教授 (90359620)
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| Co-Investigator(Kenkyū-buntansha) |
AIZAWA Kenichi 東京大学, 医学部附属病院, 特任助教 (70436484)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 循環器・高血圧 / 蛋白質 / プロテオーム / ストレス / 動脈硬化 |
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| Research Abstract |
It is revealed that endocrine control participates in the condition of a patient of the cardiovascular disease and in late years attracts attention as the field of cardiovascular endocrinology. We pursued the generation mechanism of the fragment which selective bioactive peptide caught the processing to heart seen at the time of arteriosclerosis. We examined whether human recombinant performed a process of this bioactive peptide using a mass spectrometer. In addition, we performed examination whether or not the activity of this enzyme was seen in blood and examined correlation with the condition of a patient. As a result, in the coronary restenotic condition of a patient, we made clear that a piece of the specific bioactive peptide decreased. It is expected future arteriosclerotic new diagnostic agent, that, besides, it is a beginning of the development of the antiarteriosclerotic drug.
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Author(s)
Enokoku K, Ikeda H, Kato R, Kume Y, Yoshida H, Ono T, Aizawa K, Suzuki T, Yamzaki T, Yatomi Y.
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Journal Title
Clin. Chim. Acta
Volume: 421
Pages: 147-151
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[Journal Article] Type-selective benefits of medications in treatment of acute aortic dissection; (from the International Registry of Acute Aortic Dissection [IRAD])2012
Author(s)
Suzuki T , Isselbacher EM, Nienaber CA, Pyeritz RE, Eagle KA, Tsai TT, Cooper JV, Januzzi JL Jr, Braverman AC, Montgomery DG, Fattori R, Pape L, Harris KM, Booher A, Oh J, Peterson M, Ramanath VS, Froehlich JB.
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Journal Title
Am J Cardiol
Volume: 109
Pages: 122-127
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