2013 Fiscal Year Final Research Report
Cysteine Protease Cathepsin K: A New Biomarker in Patients with Atrial Fibrillation
Project/Area Number |
24659385
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Nagoya University |
Principal Investigator |
XIAN WU Cheng 名古屋大学, 医学(系)研究科(研究院), 特任准教授 (30378228)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | カテプシンK / 心房細動 / 心房リモデリング / マトリックス蛋白 / バイオマーカー |
Research Abstract |
We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression and therapeutic target for CatK. Plasma levels of CatK were measured in patients with AF (paroxysmal AF [PAF]; persistent AF [PeAF]) and control subjects. AF had higher CatK than did controls. PeAF had higher CatK levels than PAF. CatK was correlated left atrial diameter in all subjects. The levels of atrial tissue angiotensin II, AT1R, gp91phox, p-p38MAPK, and CatK; O2-; and CatK activity; and fibrosis were greater in rabbits with AF than in that of controls, and these changes were reversed by AT1R blocker (ARB). Olmesartan decreased the CatK expression induced by angiotensin II in neonatal myocytes. These data indicated that increased plasma CatK levels are linked with the presence of AF. ARB appears to be effective in alleviating atrial fibrosis in a rabbit AF model, partly reducing AT1R-p38MAPK-dependent and -independent CatK activation, thus preventing AF.
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Research Products
(25 results)
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[Journal Article] Cathepsin K-Mediated Notch1 Activation Contributes to Neovascularisation in Response to Hypoxia2014
Author(s)
Jiang H, Cheng XW, Shi GP, Hu L, Inoue A, Yamamura Y, Wu H, Takeshita K, Li X, Huang Z, Song H, Asai M, Hao CN, Unno K, Koike T, Oshida Y, Okumura K, Murohara T, Kuzuya M.
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Journal Title
Nature Communications
Volume: (in press)
Peer Reviewed
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[Journal Article] Impact of Lysophosphatidylcholine on Survival and Function of UEA-1^+acLDL^+ Endothelial Progenitor Cells in Patients with Coronary Artery Disease2014
Author(s)
Hong SH, Jang HH, Lee SR, Lee KH, Woo JS, Kim JB, Kim WS, Min BI, Cho KH, Kim KS, Cheng XW, Kim W.
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Journal Title
Heart & Vessels
Volume: (Epub ahead of print)
Peer Reviewed
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[Journal Article] Circulating Cathepsin K as a Potential Novel Biomarker of Coronary Artery Disease2013
Author(s)
Cheng XW, Kikuchi R, Ishii H, Yoshikawa D, Hu L, Takahashi R, Shibata R, Ikeda N, Kuzuya M, Okumura K, Murohara T.
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Journal Title
Atherosclerosis
Volume: 228
Pages: 211-216
DOI
Peer Reviewed
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[Journal Article] Relationship between Myocardial Fibrosis and Left Ventricular Function in Nonischemic Dilated Cardiomyopathy : A Comparison Focal and Interstitial Fibrosis2013
Author(s)
Yamada T, Hirashiki A, Cheng XW, Okumura T, Shimazu S, Okamoto R, Shinoda N, Isobe S, Takeshita K, Shinji N, Kondo T, Murohara T.
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Journal Title
Journal of Cardiac Failure
Volume: 19 (8)
Pages: 557-564
DOI
Peer Reviewed
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[Journal Article] Increased ^<99m>Tc-sestamibi washout reflects impaired myocardial contractile and relaxation reserve during dobutamine stress due to mitochondrial dysfunction in dilated cardiomyopathy2013
Author(s)
Hayashi D, Ohshima S, Isobe S, Cheng XW, Unno K, Funahashi H, Shinoda N, Okumura T, Hirashiki A, Kato K, Murohara T.
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Journal Title
The Journal of Americal Colleage and Cardilogy
Volume: 61(19)
Pages: 2007-2017
DOI
Peer Reviewed
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[Journal Article] Mechanisms with Clinical Implications for Atrial Fibrillation -Associated Remodeling : Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker2013
Author(s)
Fujita M, Cheng XW, Inden Y, Yoshida N, Kitamura K, Shimano M, Hu L, Shi GP, Kuzuya M, Okumura K, Murohara T.
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Journal Title
Jouenal of the American Heart Association
Volume: 2(6)
Pages: e000503
DOI
Peer Reviewed
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