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2013 Fiscal Year Final Research Report

Cysteine Protease Cathepsin K: A New Biomarker in Patients with Atrial Fibrillation

Research Project

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Project/Area Number 24659385
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

XIAN WU Cheng  名古屋大学, 医学(系)研究科(研究院), 特任准教授 (30378228)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsカテプシンK / 心房細動 / 心房リモデリング / マトリックス蛋白 / バイオマーカー
Research Abstract

We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression and therapeutic target for CatK. Plasma levels of CatK were measured in patients with AF (paroxysmal AF [PAF]; persistent AF [PeAF]) and control subjects. AF had higher CatK than did controls. PeAF had higher CatK levels than PAF. CatK was correlated left atrial diameter in all subjects. The levels of atrial tissue angiotensin II, AT1R, gp91phox, p-p38MAPK, and CatK; O2-; and CatK activity; and fibrosis were greater in rabbits with AF than in that of controls, and these changes were reversed by AT1R blocker (ARB). Olmesartan decreased the CatK expression induced by angiotensin II in neonatal myocytes. These data indicated that increased plasma CatK levels are linked with the presence of AF. ARB appears to be effective in alleviating atrial fibrosis in a rabbit AF model, partly reducing AT1R-p38MAPK-dependent and -independent CatK activation, thus preventing AF.

  • Research Products

    (25 results)

All 2014 2013 2012

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Cathepsin K-Mediated Notch1 Activation Contributes to Neovascularisation in Response to Hypoxia2014

    • Author(s)
      Jiang H, Cheng XW, Shi GP, Hu L, Inoue A, Yamamura Y, Wu H, Takeshita K, Li X, Huang Z, Song H, Asai M, Hao CN, Unno K, Koike T, Oshida Y, Okumura K, Murohara T, Kuzuya M.
    • Journal Title

      Nature Communications

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Impact of Lysophosphatidylcholine on Survival and Function of UEA-1^+acLDL^+ Endothelial Progenitor Cells in Patients with Coronary Artery Disease2014

    • Author(s)
      Hong SH, Jang HH, Lee SR, Lee KH, Woo JS, Kim JB, Kim WS, Min BI, Cho KH, Kim KS, Cheng XW, Kim W.
    • Journal Title

      Heart & Vessels

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mTOR and FoxO1/3a phosphorylations and alleviates TNF-α/IFN-γ-induced MuRF-1 expression in C2C12 cells2014

    • Author(s)
      Kimura K, Cheng XW, Inoue A, Hu L, Koike T, Kuzuya M.
    • Journal Title

      Nutrition Research

      Volume: 34(4) Pages: 368-374

    • DOI

      10.1016/j.nutres.2014.02.003

    • Peer Reviewed
  • [Journal Article] Cathepsin K Activity Controls Injury- Related Vascular Repair in Mice2014

    • Author(s)
      Hu L, Cheng XW, Song H, Inoue A, Jiang H, Li X, Shi GP, Kozawa E, Okumura K, Kuzuya M.
    • Journal Title

      Hypertension

      Volume: 63(3) Pages: 607-15

    • DOI

      10.1161/HYPERTENSIONAHA.113.02141

    • Peer Reviewed
  • [Journal Article] Digesting the Atherosclerosis-like Lesion-Based Remodeled Vasculature : The Role of Cysteinyl Cathepsins in Venous Disorder (editorial)2014

    • Author(s)
      Cheng XW, Sasaki T, Kuzuya M.
    • Journal Title

      Thrombosis and Heamostasis

      Volume: 112(1)(Epub ahead of print)

    • DOI

      10.1160/TH13-10-0889

    • Peer Reviewed
  • [Journal Article] Circulating Cathepsin K as a Potential Novel Biomarker of Coronary Artery Disease2013

    • Author(s)
      Cheng XW, Kikuchi R, Ishii H, Yoshikawa D, Hu L, Takahashi R, Shibata R, Ikeda N, Kuzuya M, Okumura K, Murohara T.
    • Journal Title

      Atherosclerosis

      Volume: 228 Pages: 211-216

    • DOI

      10.1016/j.atherosclerosis.2013.01.004

    • Peer Reviewed
  • [Journal Article] GLP-1R Agonists for the Prevention of Cardiac Injury in STEMI Patients Undergoing PCI : Something New and Promising, or Not?2013

    • Author(s)
      Cheng X, Murohara T, Kuzuya M.
    • Journal Title

      International Journal of Cardiology Metabolic and Endocrine

      Volume: 1 Pages: 1-3

    • DOI

      10.1016/j.ijcme.2013.10.003

    • Peer Reviewed
  • [Journal Article] Relationship between Myocardial Fibrosis and Left Ventricular Function in Nonischemic Dilated Cardiomyopathy : A Comparison Focal and Interstitial Fibrosis2013

    • Author(s)
      Yamada T, Hirashiki A, Cheng XW, Okumura T, Shimazu S, Okamoto R, Shinoda N, Isobe S, Takeshita K, Shinji N, Kondo T, Murohara T.
    • Journal Title

      Journal of Cardiac Failure

      Volume: 19 (8) Pages: 557-564

    • DOI

      10.1016/j.cardfail.2013.05.018

    • Peer Reviewed
  • [Journal Article] Regulation of Apelin and its Receptor Expression in Adipose Tissues of Obesity Rats with Hypertension and Cultured 3T3-L1 Adipocytes2013

    • Author(s)
      Wu HX, Cheng XW, Hao C, Zhang Z, Yao H, Murohara T, Dai Q.
    • Journal Title

      Experimental Animals

      Volume: (acceptance)

    • Peer Reviewed
  • [Journal Article] Circulating cf-DNA : A Promising, Noninvasive Tool for Assessment of Early Cardio-Metabolic Risk (editorials)2013

    • Author(s)
      Song H, Nan YS, Cheng XW.
    • Journal Title

      Atherosclerosis

      Volume: 233 Pages: 307-309

    • DOI

      10.1016/j.atherosclerosis.2013.11.081

    • Peer Reviewed
  • [Journal Article] Association between cardiopulmonary mparison with peak VO₂and VE/VCO₂slope2013

    • Author(s)
      Okumura T, Hirashiki T, Yamada S, Funahashi H, Oshima S, Kono Y, Cheng XW, Takeshita K, Muroahra T.
    • Journal Title

      International Journal of Cardiology

      Volume: 162(3) Pages: 234-239

    • DOI

      10.1016/j.ijcard.2011.05.065

    • Peer Reviewed
  • [Journal Article] Usefulness of serum cardiac troponins T and I to predict cardiac molecular changes and cardiac damage in patients with hypertrophic cardiomyopathy2013

    • Author(s)
      Okamoto R, Hirashiki A, Cheng XW, Shinoda N, Okumura T, Takeshita K, Bando Y, Murohara T.
    • Journal Title

      International Heart Journal

      Volume: 54(4) Pages: 202-206

    • DOI

      10.1536/ihj.54.202

    • Peer Reviewed
  • [Journal Article] Increased ^<99m>Tc-sestamibi washout reflects impaired myocardial contractile and relaxation reserve during dobutamine stress due to mitochondrial dysfunction in dilated cardiomyopathy2013

    • Author(s)
      Hayashi D, Ohshima S, Isobe S, Cheng XW, Unno K, Funahashi H, Shinoda N, Okumura T, Hirashiki A, Kato K, Murohara T.
    • Journal Title

      The Journal of Americal Colleage and Cardilogy

      Volume: 61(19) Pages: 2007-2017

    • DOI

      10.1016/j.jacc.2013.01.074

    • Peer Reviewed
  • [Journal Article] Effect of Aged Garlic Extract on Left Ventricular Diastolic Function and Fibrosis in Rats Model of Hypertension2013

    • Author(s)
      Hara Y, Noda A, Miyata S, Minoshima M, Sugiura M Kojima J, Otake M, Furukawa M, Cheng XW, Nagota K, Murohara T.
    • Journal Title

      Experimental Animals

      Volume: 62(4) Pages: 305-310

    • DOI

      10.1538/expanim.62.305

    • Peer Reviewed
  • [Journal Article] The power combination of blood-pressure parameers to predict the incidence of plaque formation in carotid arteries in elderly2013

    • Author(s)
      Hao CH, Shi YQ, Huang JJ, Li HY, Huang ZH, Cheng XW, Lu W, Duan JL.
    • Journal Title

      International Journal of Clinical and Experimental Medicine

      Volume: 6(6) Pages: 461-469

    • URL

      http://www.ijcem.com/ISSN:1940-5901/IJCEM1305006

    • Peer Reviewed
  • [Journal Article] Mechanisms with Clinical Implications for Atrial Fibrillation -Associated Remodeling : Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker2013

    • Author(s)
      Fujita M, Cheng XW, Inden Y, Yoshida N, Kitamura K, Shimano M, Hu L, Shi GP, Kuzuya M, Okumura K, Murohara T.
    • Journal Title

      Jouenal of the American Heart Association

      Volume: 2(6) Pages: e000503

    • DOI

      10.1161/JAHA.113.000503

    • Peer Reviewed
  • [Journal Article] Matrix Metalloproteinase-2 deficiency Impairs Aortic Atherosclerotic Calcification in atherosclerotic in ApoE- deficient old mice2013

    • Author(s)
      Sasaki T, Nakamura K, Sasada K, Okata S, Cheng XW, Suzuki S, Murohara T, Sato K, Kuzuya M.
    • Journal Title

      Atherosclerosis

      Volume: 227 Pages: 43-50

    • DOI

      10.1016/j

    • Peer Reviewed
  • [Presentation] The Progress in Angiogenesis Research : Focusing on Notch1 Activation and Cathepsin K2013

    • Author(s)
      Cheng XW.
    • Organizer
      Myocardial Ischemia Symposium in Korea 2013 (MIS-Korea)
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2013-09-28
  • [Presentation] Cathepsin K-A Classical Bone Biomarker in Cardiovascular Disease : The heart is not alone anymore2013

    • Author(s)
      Cheng XW.
    • Organizer
      The 3rd East Asia International Cardiovascular Symposium
    • Place of Presentation
      哈爾濱(中国)
    • Year and Date
      2013-08-09
  • [Presentation] Mechanisms Underlying the Impairment of Ischemia- Induced Neovascularization in Cathepsin K- Deficient Mice : Impact on Noich1 activation2013

    • Author(s)
      姜海英,成憲武,胡麗娜,井上愛子,史国平,奥村健二,葛谷雅文
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2013-03-15
  • [Presentation] Mechanisms Underlying the Impairment of Ischemia-Induced Neovascularization in Cathepsin K-Deficient Mice2012

    • Author(s)
      Jiang HY, Cheng XW, Shi GP, Hu L, Inoue A, Song H, Huang Z, Okumura K, Kuzuya M.
    • Organizer
      American Heart Association.Scientific Sections 2012
    • Place of Presentation
      ロサンゼルス(アメリカ)
    • Year and Date
      2012-11-05
  • [Presentation] Anti-Vascular Aging : Impact on Exercise and EPCs2012

    • Author(s)
      Cheng XW.
    • Organizer
      The 3rd International Symposium on the Frontiers in Cardiovascular Diseases (3rd ISFC)
    • Place of Presentation
      廈門市(中国)
    • Year and Date
      2012-09-22
  • [Presentation] Cysteine Protease Cathepsin K : A New Biomarker in Patients with Atrial Fibrillation2012

    • Author(s)
      藤田雅也,成憲武,因田恭也,吉田直樹,嶋野祐之,奥村健二,室原豊明
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      ホテル日航金沢ほか(金沢市)
    • Year and Date
      2012-09-15
  • [Presentation] Exploration of Mechanisms of Atherosclerotic Plaque Rupture From A New and Simple Mouse Model of Plaque Rupture2012

    • Author(s)
      成憲武,胡麗娜,井上愛子,佐々木健,木村薫,室原豊明,葛谷雅文
    • Organizer
      第44回日本動脈硬化学会総会・学術集会(シンポジウム)
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Year and Date
      2012-07-19
  • [Book] 血管新生研究の最先端-血管新生研究の最先端.血管新生におけるインテグリンの役割(佐藤靖史,高倉伸幸編)2013

    • Author(s)
      成憲武,室原豊明
    • Total Pages
      332(226- 233)
    • Publisher
      医薬ジャーナル社

URL: 

Published: 2015-06-25  

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