2014 Fiscal Year Final Research Report
Genetic analysis of smoking behavior
| Project/Area Number |
24659400
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 喫煙習慣 / 禁煙 / 遺伝因子 |
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| Outline of Final Research Achievements |
We have conducted GWAS for smoking behaviour using 1369 healthy Japanese adults. Smoking behaviour was evaluated by smoking status (current, ex or never) and smoking index. Although we failed to identify significant associations at any chromosomal regions at the GWAS level significance, some of the previously reported genes for smoking behaviour in non-Japanese populations showed some associations with smoking status and/or smoking index. These genes included genes encoding serotonin 2A receptor (HTR2A) and neurexin 1 (NRXN1). In 56 smoking individuals who completed 8 weeks of smoking cessation clinic, none of these genetic factors were related to success or failure of smoking cessation.
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| Free Research Field |
呼吸器内科
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