Elucidation of the involvement of the inflammatory response and development of a new marker and treatment in lung cancer growth

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659407
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Kagoshima University
• Principal Investigator: MIZUNO Keiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (50531414)
• Co-Investigator(Kenkyū-buntansha): INOUE Hiromasa 鹿児島大学, 大学院医歯学総合研究科呼吸器内科学, 教授 (30264039)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺癌 / マイクロアレイ / マイクロRNA / 遺伝子 / miR-1/133a

Outline of Final Research Achievements

The results of the microarray analysis in lung squamous cell carcinoma clinical specimens was extracted several microRNA group showed a significant decrease in expression as compared to normal lung tissue. Among them which is one miR-1 / 133a cluster of has been reported decreased expression in bladder cancer, head and neck cancer and the like, in the present study revealed that there is a tumor suppressor effect in lung squamous cell carcinoma. Also inhibition of the target gene I got results suggest that are deeply involved in the migration and invasion suppressor function of cancer cells. Furthermore miR-206 is I revealed to have an inhibitory action of key genes in lung cancer. The elucidation of the tumor suppression mechanism it was considered that there is a possibility that lead to the development of future new therapies.

Free Research Field

医歯薬学