siRNA carrier strategy to inhibit to rejection of transplanted kidneys

2015 Fiscal Year Final Research Report

• Project/Area Number: 24659411
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Watanabe Sumiyo 東京大学, 医学(系)研究科(研究院), 研究員 (30422314)
• Co-Investigator(Kenkyū-buntansha): OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623) ; UCHIDA Shunya 帝京大学, 医学部, 教授 (50151882) ; FUKUSHIMA Shigeto 東京大学, 大学院工学系研究科, 研究員 (60625680)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 腎移植拒絶反応 / 免疫寛容 / 遺伝子治療 / siRNA / siRNAキャリアー

Outline of Final Research Achievements

Japanese economy would collapse in this state by the immeasurable increasing medical costs.Therefore, we aim to reduce the medical costs while providing higher-quality medical care.In the case of kidney dialysis,which takes more than a trillion yen per year and the QOL is low.Meanwhile, kidney transplant requires only one-third of the expense, and the QOL becomes higher.One of the serious problems that transplant is not performed is the low successful rate of engraftment of the transplanted kidneys caused by immunological rejection.On the other hand, suppressing immune system causes many side effects. Therefore, we tried to make recognize transplanted kidneys as "self" to immune system. For the purpose, we designed CD40 and CD40L siRNA and create artificial vector to carry siRNA to the transplanted blood vessels in the transplanted kidneys.

Free Research Field

腎臓内分泌内科　遺伝子治療