2013 Fiscal Year Final Research Report
Analysis of mitochondrial regeneration with cellular models of Parkinson's disease
| Project/Area Number |
24659435
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
SAIKI Shinji 順天堂大学, 医学部, 准教授 (00339996)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Kojiro 大阪工業大学, 情報科学部, 准教授 (10612442)
AMO Taku 防衛大学校, 応用化学群, 助教 (40453922)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脳神経疾患 / 再生医療 |
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| Research Abstract |
20-30 % of HeLa cells transiently expressing PINK1/parkin, Parkinson's disease-asssociated genes, have shown apoptotic changes characterized by elevation of levels of cleaved caspase-8/9/3. The apoptosis induced by PINK1/parkin overexpression is inhibited by zVAD as well as caspase-8 inhibitors. Now we try to sort out cells with less mitochondria without apoptotic tendency and figure out the characteristics.
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[Journal Article] p150glued-associated disorders are caused by activation of intrinsic apoptotic pathway
Author(s)
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
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Journal Title
PLOS ONE
Volume: (in press)
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