2013 Fiscal Year Final Research Report
Role of INTS6 in the adipose differentiation
| Project/Area Number |
24659445
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ＩＮＴＳ６ / 脂肪細胞 / 代謝 / 分化 / 肥満 |
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| Research Abstract |
We demonstrated that expression levels ofIntS6 and IntS11, subunits ofthe Integrator complex, were increased in 3T3-L1 cells in the period when the cells reach edconfluenceand differentiated into adipocytes, while being reduced tobasal levels after the completion ofdifferentiation. Suppre ssion of IntS6 or IntS11 expression using siRNAs in3T3-L1 pre-adipocytes markedly inhibited differentiation into mature adipocytes. These findings demonstrate that increased expression of Integrator complex subunits is an indispensable event in adipose differentiation. Although further study is necessary to elucidate the underlying mechanism, the processing of U1, U2 small nuclear RNAs may be involved in cell differentiation steps.
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Research Products
(43 results)
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[Journal Article] Valsartan, independently of AT1 receptor or PPAR, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012
Author(s)
Iwashita, M., Sakoda, H., ,Nakatsu, Y., Asano, T.
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Journal Title
Am. J. Physiol. Endo. Metab
Volume: 302
Pages: E286-96
Peer Reviewed
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