2013 Fiscal Year Final Research Report
Effect of thyroid hormone to muscle hypertrophy by aerobic training.
| Project/Area Number |
24659449
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
KOIBUCHI NORIYUKI 群馬大学, 医学(系)研究科(研究院), 教授 (80234681)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Toshiharu 群馬大学, 大学院医学系研究科, 講師 (80375576)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 有酸素運動 / 骨格筋 / 甲状腺ホルモン / NaK-ATPase |
|---|
| Research Abstract |
Aerobic exercise facilitates oxidative phosphorylation and glycolysis of skeletal muscle. Thyroid hormone (TH) also facilitates such metabolic events. We studied whether TH signaling pathway is activated by aerobic training using rat treadmill exercise model. Male adult rats received 30 min/day treadmill training with different exercise intensity for 12 days. We determined exercize intensity by plasma lactate levels. TSH level was suppressed in both aerobic and anaerobic groups during the exercise. TRbeta1 mRNA and protein levels were augmented by aerobic but not anaerobic training. Aerobic training also augmented T3-activated NaK-ATPase mRNA expression. Aerobic training alters TH signaling at least in part by increasing TRbeta1 expression.
|
-
[Journal Article] Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism2014
Author(s)
Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Kasagi M, Masuda H, Jingu H, Furudate SI, Haijima A, Takatsuru Y, Iwasaki T, Umezu M, Koibuchi N.
-
Journal Title
J Neuroendocrinol
Volume: 26
Pages: 164-175
DOI
Peer Reviewed
-
[Journal Article] Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines2014
Author(s)
Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T.
-
Journal Title
J Neurochem
Volume: 128
Pages: 507-522
DOI
Peer Reviewed
-
[Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder2014
Author(s)
Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N.
-
Journal Title
Physiological Rep
Volume: 2
Pages: e00197
DOI
Peer Reviewed
-
-
[Journal Article] Effects of perinatal lipopolysaccharide (LPS) exposure on the developing rat brain; modeling the effect of maternal infection on the developing human CNS2013
Author(s)
Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM.
-
Journal Title
Cerebellum
Volume: 12
Pages: 572-586
DOI
Peer Reviewed
-
-
-
-
-
[Journal Article] Alterations of biochemical marker levels and myonuclear numbers in rat skeletal muscle after ischemia-reperfusion2013
Author(s)
Itoh M, Shimokawa N, Tajika Y, Murakami T, Aotsuka N, Lesmana R, Farenia R, Iwasaki T, Okada J, Yorifuji H, Koibuchi N.
-
Journal Title
Mol Cell Biochem
Volume: 373
Pages: 11-18
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] New challenge of Physiological Society of Japan – Reform of annual meeting and establishment of Physiology Educator role2013
Author(s)
Koibuchi N, Nakashima A, Ishimatsu M, Okumura S, Okumura T, Kawai Y, Kuno M, Koizumi A, Shiibashi M, Suzuki A, Matsuda T, Morita H, Yamashita T, Yamanaka A.
Organizer
37^<th> International Congress of Physiological Society
Place of Presentation
Birmingham, UK
Year and Date
20130721-26
-
[Presentation] New challenge of Physiological Society of Japan – Reform of annual meeting and establishment of Physiology Educator role2013
Author(s)
Koibuchi N, Nakashima A, Ishimatsu M, Okumura S, Okumura T, Kawai Y, Kuno M, Koizumi A, Shiibashi M, Suzuki A, Matsuda T, Morita H, Yamashita T, Yamanaka A.
Organizer
The IUPS and ADInstruments Teaching Workshop
Place of Presentation
Bristol, UK
Year and Date
20130718-21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
