2012 Fiscal Year Final Research Report
Concept of Physiologic Inflammation and Its Functional Significance
| Project/Area Number |
24659450
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OGAWA Yoshihiro 東條医科歯科大学, 大学院・医歯学総合研究科, 教授 (70291424)
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| Project Period (FY) |
2012
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| Keywords | 内分泌学 |
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| Research Abstract |
The data of this study suggest that pro-inflammatory M1 macrophages infiltrated into adipose tissue of pregnant mice induce insulin resistance via increased adipocyte lipolysis, thereby resulting in stable supply of energy to fetus. Our data also suggest that transient and reversible physiologic inflammation of adipose tissue in pregnant mice plays an important role in homeostasis both dam and fetus.
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[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
Author(s)
Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y
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Journal Title
Diabetes
Volume: 61
Pages: 1199-1209
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[Journal Article] Highly purified eicosapentaenoic acid increasesinterleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia2012
Author(s)
Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Hasegawa K, Ogawa Y
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Journal Title
Diabetes Care
Volume: 35
Pages: 2631-2639
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