2013 Fiscal Year Final Research Report
Mechanism of emerging infection with highly pathogenic Cryptococcus gattii
| Project/Area Number |
24659477
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHII Keiko 東北大学, 医学(系)研究科(研究院), 准教授 (00291253)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Kazuyoshi 東北大学, 大学院医学系研究科, 教授 (10253973)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | クリプトコックス・ガッティ / 高病原性 / オバルブミン / T細胞サブセット / 免疫応答性 |
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| Research Abstract |
The aim of this study is to clarify the protective immune responses to a highly pathogenic Cryptococcus gattii. During the study period, we found that highly pathogenic strains with thick capsule escaped from the recognition by dendritic cells. We also successfully transformed several kinds of cryptococcal strains with Gallus ovalbumin (OVA) gene by using the biolistic method. With the transformed cryptococcal strains and transgenic (Tg) mice expressing OVA-specific T cell receptors, we built a novel assay system for studies on protective immune response to C. gattii.
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[Journal Article] Defect of CARD9 leads to impaired accumulation of IFN-γ-producing memory-phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans2014
Author(s)
Yamamoto H, Nakamura Y, Sato K, Takahashi Y, Nomura T, Miyasaka T, Ishii K, Hara H, Yamamoto N, Kanno E, Iwakura Y, Kawakami K.
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Journal Title
Infect. Immun
Volume: 82
Pages: 1606-15
DOI
Peer Reviewed
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[Journal Article] Involvement of Gr-1dull+ cells in the production of TNF-αand IL-17 and exacerbated systemic inflammatory response caused by lipopolysaccharide2014
Author(s)
Tanno D, Akahori Y, Toyama M, Sato K, Kudo D, Abe Y, Miyasaka T, Yamamoto H, Ishii K, Kanno E, Maruyama R, Kushimoto S, Iwakura Y, Kawakami K.
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Journal Title
Inflammation
Volume: 37
Pages: 186-195
URL
Peer Reviewed
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[Journal Article] Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine2013
Author(s)
Miyasaka T, Akahori Y, Toyama M, Miyamura N, Ishii K, Saijo S, Iwakura Y, Kinjo Y, Miyazaki Y, Oishi K, Kawakami K.
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Journal Title
PLoS One
Volume: 8
Pages: e78611
DOI
Peer Reviewed
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