2013 Fiscal Year Final Research Report
Characterization of malignant glioma and development of potent treatment strategy focusing on hypoxia dynamics
| Project/Area Number |
24659551
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
INANAMI Osamu 北海道大学, (連合)獣医学研究科, 教授 (10193559)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMORI Tohru 北海道大学, 大学院獣医学研究科, 准教授 (00512675)
YASUI Hironobu 北海道大学, 大学院獣医学研究科, 助教 (10570228)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脳腫瘍 / 低酸素 / イメージング / 放射線治療 / 核医学イメージング / 電子スピン共鳴 |
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| Research Abstract |
The purpose of this study is to clarify the hypothesis that the frequency of tumor hypoxia influences the prognosis of malignant glioma rather than an amount of tumor hypoxia. The results revealed that sequential PET analysis using 18F-FMISO could not visualize the transient hypoxia in glioma, because it took the relatively long time for the radioactivity attenuation. However, this study achieved the establishment of hypoxia imaging in transplanted murine glioma by using electron spin resonance technique. Furthermore, it was revealed that doranidazole is a potent drug to improve the radiation efficiency against hypoxic glioma cells.
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Research Products
(39 results)
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[Journal Article] Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles2014
Author(s)
Yasui H., Takeuchi R., Nagane M., Meike S., Nakamura Y., Yamamori T., Ikenaka Y., Kon Y., Murotani H., Oishi M., Nagasaki Y., and Inanami O
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Journal Title
Cancer Lett
Volume: 347(1)
Pages: 151-158
Peer Reviewed
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[Journal Article] EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate2013
Author(s)
Matsumoto S., Saito K., Yasui H., Morris H.D., Munasinghe J.P., Lizak M., Merkle H., Ardenkjaer-Larsen J.H., Choudhuri R., Devasahayam N., Subramanian S., Koretsky A.P., Mitchell J.B., and Krishna M.C
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Journal Title
Magn. Reson. Med
Volume: 69(5)
Pages: 1443-1450
Peer Reviewed
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[Journal Article] Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line2012
Author(s)
Indo H.P., Inanami O., Koumura T., Suenaga S., Yen H.C., Kakinuma S., Matsumoto K., Nakanishi I., St. Clair W., St. Clair D.K., Matsui H., Cornette R., Gusev O., Okuda T., Nakagawa Y., Ozawa T., and Majima H.J
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Journal Title
HLE. Free Radic. Res
Volume: 46(8)
Pages: 1029-1043
Peer Reviewed
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