2013 Fiscal Year Final Research Report
Analysis for disease mechanism by intracellular elements using microparticle beam
| Project/Area Number |
24659556
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 量子ビーム |
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| Research Abstract |
In the present generation, the trace elements are taken in human body and these cause several disease. The trace elements have shown close correlation of treatment resistant disease, such as Parkinson disease. In cancer therapy, some trace elements are used as an anticancer agent. In this research, mechanisms of disease & treatment effect are analyzed by measuring trace element distribution in cell. In analysis for sample from atypical pneumonia, many elements, such as iron, nickel, chromium, aluminium, were seen simultaneously as one image. By using cultured cells in vitro, uptake of cis-platinum to cells were seen, and amount of platinum could be estimated. This study is useful for scientific diagnosis for treatment resistant disease in recent society.
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