Basic research on Sophistication of Medical Si/CdTe compton camera

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659557
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: NAKANO Takashi 群馬大学, 医学(系)研究科(研究院), 教授 (20211427)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Hirohumi 群馬大学, 重粒子線医学推進機構, 助教 (10414575) ; KATO Hiroyuki 群馬大学, 重粒子線医学推進機構, 助教 (30334121) ; SUZUKI Yoshiyuki 群馬大学, 大学院医学系研究科, 准教授 (60334116) ; YOSHIDA Yukari 群馬大学, 重粒子線医学推進機構, 助教 (90431717) ; TORIKAI Kouta 群馬大学, 先端科学研究指導者育成ユニット, 助教 (90443077)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: コンプトンカメラ / 粒子線治療 / 核医学診断

Research Abstract

We developed Si/CdTe Compton camera for medical use which can measure gannma-rays from the Tc-99m up to F-18. Then, we succeeded simultaneously to measure two types of RI distributions of F-18FDG and I-133 and to obtain three-dimensional imaging of the two RI distribution administered to a rat.
We succeeded to conduct clinical study of administration of 18F-FDG and 99mTc-DMSA, drugs for nuclear medicine diagnostic, in a human to obtain simultaneous imaging of the two RI by the clinical Si/CdTe Compton camera first in the world. In clinical, by simultaneous measurement method by multiple RI drugs, a significant reduction in testing time is expected. In addition, the development of RI diagnostic techniques of tracing simultaneous disposition of multiple RI drugs is expected to lead to the creation of a new scientific area such as bio-dynamics study by the tracing and the study to clarify the mechanisms of malignant transformation of cancer cells.

Research Products

• [Journal Article] Three-dimensional and multienergy gamma-ray simultaneous imaging by using a Si/CdTe Compton camera (2013)
  • Author(s): Suzuki Y, Yamaguchi M, Odaka H, Shimada H, Yoshida Y, Torikai K, Satoh T, Arakawa K, Kawachi N, Watanabe S, Takeda S, Ishikawa SN, Aono H, Watanabe S, Takahashi T, Nakano T
  • Journal Title: Radiology Volume: 267(3) Pages: 941-7
• [Journal Article] Beam range estimation by measuring bremsstrahlung (2012)
  • Author(s): Yamaguchi M, Torikai K, Kawachi N, Shimada H, Satoh T, Nagao Y, Fujimaki S, Kokubun M, Watanabe S, Takahashi T, Arakawa K, Kamiya T, Nakano T
  • Journal Title: Phys Med Biol Volume: 57(10) Pages: 2843-56
• [Journal Article] Applications and Imaging Techniques of a Si/CdTe Compton Gamma-Ray Camera (2012)
  • Author(s): Takeda, S., Ichinohe, Y., Hagino, K., Odaka, H., Yuasa, T., Ishikawa, Shinya Saito, Tamotsu Satoa, Goro Sato, Shin Watanabe, Motohide Kokubun, Tadayuki Takahashi, Mitsutaka Yamaguchi, Hiroyasu Tajima, Takaaki Tanaka, Kazuhiro Nakazawa, Yasushi Fukazawa, Nakano, T
  • Journal Title: Physics Procedia Volume: 37 Pages: 859-66
• [Presentation] 医学用Si/CdTe半導体コンプトンカメラの体幹部における散乱が画質に与える影響 (2014)
  • Author(s): 酒井真理,菊地美貴子,鳥飼幸太,荒川和夫,山口充孝,長尾悠人,河地有木,藤巻秀,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,中野隆史
  • Organizer: 第53回日本生体医工学会大会
  • Year and Date: 2014-06-24
• [Presentation] 医学・生物学用マルチヘッドSi/CdTe半導体コンプトンカメラのための横断断層撮像画質のシミュレーションによる評価 (2014)
  • Author(s): 山口充孝,酒井真理,長尾悠人,河地有木,藤巻秀,荒川和夫,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,鳥飼幸太,中野隆史
  • Organizer: 第61回応用物理学会春季学術講演会
  • Year and Date: 2014-03-17
• [Presentation] (2014)
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T
  • Organizer: The 2nd International Symposium of Gunma University Program for Leading Graduate School
  • Year and Date: 2014-01-24
• [Presentation] Carbon beam microsurgery and medical compton camera for next generation microsurgery system (2013)
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T
  • Organizer: AMDE2013
  • Year and Date: 2013-12-19
• [Presentation] Carbon beam microsurgery and medical compton camera for next generation brain surgery (2013)
  • Author(s): Torikai K., Suzuki Y., Arakawa K., Noda S., Sakai M., Tashiro M., Shimada H., Yoshida Y., Kubota Y., Matsumura A., Saito A., Kanai T., Yamada S., Yamaguchi M., Nagao Y., Kawachi N., Kamiya T., Takahashi T., Takeda S., Watanabe S. and Nakano T
  • Organizer: Brain and Health Informatics 2013
  • Year and Date: 2013-10-29
• [Presentation] Development of a Method Calculating Detection Efficiency Maps for Quantitative Image Reconstruction of a Compton Camera (2013)
  • Author(s): Nagao Y., Yamaguchi, M. Kawachi N., Fujimaki S., Kamiya T., Takeda S., Watanabe S., Takahashi T., Torikai K., Arakawa K., Nakano T
  • Organizer: IEEE NSS/MIC/RTSD
  • Year and Date: 2013-10-27
• [Presentation] A new beam range monitoring method by measuring low energy photons (2013)
  • Author(s): Yamaguchi M., Torikai K., Kawachi N., Shimada H., Satoh T., Nagao Y., Fujimaki S., Kokubun M., Watanabe S., Takahashi T., Arakawa K., Kamiya T., Nakano T
  • Organizer: IEEE NSS/MIC/RTSD
  • Year and Date: 2013-10-27
• [Presentation] An evaluation of three-dimensional imaging by use of Si/CdTe Compton cameras (2013)
  • Author(s): Yamaguchi M., Nagao Y., Kawachi N., Fujimaki S., Kamiya T., Odaka H., Kokubun M., Takeda S., Watanabe S., Takahashi T., Shimada H., Torikai K., Arakawa K., Nakano T
  • Organizer: IEEE NSS/MIC/RTSD
  • Year and Date: 2013-10-27
• [Presentation] 植物体内における複数元素動態の同時撮像技術の開発 (2013)
  • Author(s): 河地有木,鈴井伸郎,石井里美,尹永根,山口充孝,長尾悠人,神谷富裕,高橋忠幸,中野隆史,藤巻秀
  • Organizer: 日本土壌肥料学会2013年度名古屋大会
  • Year and Date: 2013-09-11
• [Presentation] 医学・生物学応用のためのSi/CdTe半導体コンプトンカメラの開発 (2013)
  • Author(s): 山口充孝,長尾悠人,河地有木,藤巻秀,荒川和夫,神谷富裕,小高裕和,国分紀秀,武田伸一郎,渡辺伸,高橋忠幸,鳥飼幸太,島田博文,中野隆史
  • Organizer: 第60回応用物理学会春季学術講演会
  • Year and Date: 2013-03-27
• [Presentation] コンプトンカメラの医学・生物学応用に向けた定量的画像再構成法の開発 (2013)
  • Author(s): 長尾悠人,山口充孝,河地有木,藤巻秀,神谷富裕,武田伸一郎,渡辺伸,高橋忠幸,鳥飼幸太,荒川和夫,中野隆史
  • Organizer: 第60回応用物理学会春季学術講演会
  • Year and Date: 2013-03-27
• [Presentation] Si/CdTeコンプトンカメラによる近接領域におけるガンマ線源強度分布の定量撮像を目的とした画像再構成手法の開発 (2012)
  • Author(s): 長尾悠人,山口充孝,河地有木,藤巻秀,神谷富裕,武田伸一郎,小高裕和,渡辺伸,国分紀秀,高橋忠幸,鳥飼幸太,島田博文,荒川和夫,鈴木義行,中野隆史
  • Organizer: 第14回放射線プロセスシンポジウム
  • Year and Date: 2012-06-28