Development of high-sensitive magnetic resonance imaging technique to visualize and quantify drug kinetics in various fluid spaces in human body

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659562
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: NAGANAWA Shinji 名古屋大学, 医学(系)研究科(研究院), 教授 (50242863)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳脊髄液 / 磁気共鳴画像

Outline of Final Research Achievements

Nearly 60% of human adult body comprised of water. There are various kinds of "fluid space" such as, blood pool, cerebrospinal fluid, eye ball, inner ear, saliva, intentine, lymph fluid and so on. Each space has blood-space barrier. These barriers regulate the distribution of drugs and chemicals. We developed the method to evaluate the function of these barriers in vivo, using easy and non-invasive magnetic resonance imaging technique, which is developed by us. We evaluated the unique features of each space using MR technique and gadolinium based contrast materials.We clarified the drug pharmacokinetics of various spaces.

Free Research Field

放射線科学