Therapy using alpha-emitting radionuclide

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659573
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyoto College of Medical Science
• Principal Investigator: ENDO keigo 京都医療科学大学, 公私立大学の部局等, 学長 (10115800)
• Co-Investigator(Kenkyū-buntansha): WATANABE Naoyuki 群馬県立県民健康科学大学, 公私立大学の部局等, 教授 (90311381)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: がん治療 / アルファ線 / 抗体 / ベータ線 / ＲＩ内用治療 / 放射線管理 / アスタチン211

Research Abstract

Alpha-emitter;Astatin-211(half-life 7 hours), produced by using cyclotron, can be clinically applied for the therapy of cancer patients under current regulation in Japan. For further development of alpha-emitter therapy of cancer, the establishment of production system using cyclotron, relaxation of strict regulation, and the delivery of the alpha-emitter to research institutes will be useful in Japan.
Anti-tumor antibodies were labeled with beta-emitter yttrium-90 (half-life 3 days), injected into the tumor-bearing mice repeatedly, and showed inhibition of tumor progression. Animal-tumor model, established in the present study, would be used for the basic studies of alpha-emitter therapy of cancer.

Research Products

• [Journal Article] Assessment of [^<18>F]-fluoracetate PET/CT as a tumor-imaging modality : Preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor (2014)
  • Author(s): Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K,Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T
  • Journal Title: Ann Nucl Med Volume: 28(4) Pages: 371-381
  • Peer Reviewed
• [Journal Article] Detection of vascular endothelial growth factor in colon cancer xenografts using bevacizumab based near infrared fluorophore conjugate (2014)
  • Author(s): Paudyal B, Paudyal P, Shah D, Tominaga H, Tsushima Y, Endo K
  • Journal Title: J Biomed Sci Volume: 21(1) Pages: 35
  • DOI: 10.1186/1423-0127-21-35
  • Peer Reviewed
• [Journal Article] Biological evaluation of 3-[18.F]fluoro-α-methyl-D-tyrosine ( D-18.F]FAMT)as a novel amino acid tracer for positron emission tomography (2013)
  • Author(s): Ohshima N, Hanaoka H, Tomiyama H, Kanai Y, Kaira K, Yamaguti A, Nagamori S, Oriuchi N, TsushimaY, Endo K, Ishioka N S
  • Journal Title: Ann Nucl Med Volume: 27(4) Pages: 314-324
  • DOI: 10.1007/s12149-013-0687-7
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptor-γin capillary endothelia promotes fatty acid uptake by heart during long-term fasting (2013)
  • Author(s): Goto K, Iso T, Hanaoka H, Yamaguchi A, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, Syamsunarno MR, Matsui M, Haque A, Arai M, Kunimoto F, Yokoyama T, Endo K, Gonzalez FJ, Kurabayashi M
  • Journal Title: J Am Heart Assoc Volume: 2(1) Pages: e004861
  • DOI: 10.1161/JAHA.112.004861
  • Peer Reviewed
• [Journal Article] Capillary endothelial Fatty Acid binding proteins 4 and 5 play a critical role in Fatty Acid uptake in heart and skeletal muscle (2013)
  • Author(s): Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno MR, Hishiki T, Nagahata Y, Matsui H, Arai M, Yamaguchi A, Abumrad NA, Sano M, Suematsu M, Endo K, Hotamisligil GS, Kurabayashi M
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 33(11) Pages: 2549-57
  • DOI: 10.1161/ATVBAHA.113.301588
  • Peer Reviewed
• [Journal Article] Fractionated Radioimmunotherapy with (90)Y-Labeled Fully Human Anti-CEA Antibody
  • Author(s): Hanaoka H, Kuroki M, Yamaguchi A, Achmad A, Iida Y, Higuchi T, Oriuchi N, Tsushima Y, Endo K
  • Journal Title: Cancer Biotherapy & Radiopharmaceuticals Volume: (ahead of print)
  • DOI: 10.1089/cbr.2013.1562
  • Peer Reviewed
• [Presentation] Radiation Exposure and Health Effect of Radionuclides(I-131,Cs-137) Released from the Fukushima Nuclear Power Plant (2014)
  • Author(s): 遠藤啓吾
  • Organizer: 第11回世界核医学会
  • Place of Presentation: メキシコ国カンクン市
  • Year and Date: 20140827-31
• [Presentation] Fukushima Nuclear Power Plant Accident- Medical Emergency, Radiation Exposure in Residents and Workers, Food Contamination and its Monitoring - (2013)
  • Author(s): 遠藤啓吾
  • Organizer: 第60回北米核医学会
  • Place of Presentation: カナダ国バンクーバー市
  • Year and Date: 20130608-12