Development of contrast agent of ultrasonography for visualizing pancreatic islets

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659582
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: SAKATA Naoaki 東北大学, 大学病院, 助教 (50431565)
• Co-Investigator(Kenkyū-buntansha): KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 超音波検査 / ナノバブル / 膵島移植

Research Abstract

In this study, we attempted to develop a novel contrast agent of ultrasonography aiming to visualizing transplanted pancreatic islets. The contrast agent was made by attachment of octreotide on liposome via polyethylene glycol chain, and was used after infusion of C3F8 gas. Enhanced ultrasonography using this agent for diabetic transplanted syngenetic islets showed increase of echogenicity in transplanted islets. The enhancement was significantly correlated with endocrine function of the mice.

Research Products

• [Journal Article] Strategy for clinical setting in intramuscular and subcutaneous islet transplantation (2014)
  • Author(s): Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hata T, Katayose Y, Egawa S, Unno M
  • Journal Title: Diabetes Metab Res Rev Volume: 30(1) Pages: 1-10
  • Peer Reviewed
• [Journal Article] Clinical experiences in the treatment of pancreatic arteriovenous malformation by total pancreatectomy with islet autotransplantation (2013)
  • Author(s): Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
  • Journal Title: Transplantation Volume: 96(5) Pages: e38-40
  • Peer Reviewed
• [Journal Article] Postoperative cholestasis and cholangitis after total pancreatectomy with biliary reconstruction impair the function of autotransplanted islets (2013)
  • Author(s): Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
  • Journal Title: Transplantation Volume: 96(5) Pages: e40-3
  • Peer Reviewed
• [Journal Article] Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging, and ultrasonography (2013)
  • Author(s): Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T, Egawa S, Unno M
  • Journal Title: Islets Volume: 5(5) Pages: 179-187
  • Peer Reviewed
• [Journal Article] Development of polyvinyl alcohol bioartificial pancreas with rat islets and mesenchymal stem cells (2013)
  • Author(s): Yoshimatsu G, Sakata N, Tsuchiya H, Ishida M, Motoi F, Egawa S, Sumi S, Goto M, Unno M
  • Journal Title: Transplant Proc Volume: 45(5) Pages: 1875-80
  • Peer Reviewed
• [Journal Article] Intraoperative ultrasound examination is useful for monitoring transplanted islets : a case report (2012)
  • Author(s): Sakata N, Goto M, Gumpei Y, Mizuma M, Motoi F, Satomi S, Unno M
  • Journal Title: Islets Volume: 4(5) Pages: 339-42
  • Peer Reviewed
• [Journal Article] Animal models of diabetes mellitus for islet transplantation (2012)
  • Author(s): Sakata N, Yoshimatsu G, Tsuchiya H, Egawa S, Unno M
  • Journal Title: Exp Diabetes Res Volume: 2012 Pages: 256707
  • DOI: 10.1155/2012/256707
  • Peer Reviewed
• [Presentation] 筋肉内膵島移植の臨床応用に向けて (2014)
  • Author(s): 坂田直昭、吉松軍平、土屋朗之、畠達夫、深瀬正彦、元井冬彦、内藤剛、片寄友、江川新一、海野倫明
  • Organizer: 第69回日本消化器外科学会総会
  • Place of Presentation: 郡山
  • Year and Date: 20140716-18
• [Presentation] Clinical Experiences of Islet Autotransplantation in Tohoku University (2014)
  • Author(s): 坂田直昭、後藤昌史、元井冬彦、片寄友、江川新一、下瀬川徹、里見進、海野倫明
  • Organizer: 第45回日本膵臓学会大会
  • Place of Presentation: 北九州
  • Year and Date: 20140711-12
• [Presentation] 膵島移植における神経成長因子(Nerve Growth Factor)の役割と機能解析 (2014)
  • Author(s): 畠達夫、坂田直昭、吉松軍平、土屋朗之、深瀬正彦、青木豪、川口桂、薮内伸一、深瀬耕二、水間正道、中川圭、林洋毅、岡田恭穂、森川孝則、吉田寛、元井冬彦、内藤剛、片寄友、江川新一、海野倫明
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 20140403-05
• [Presentation] Co-transplantation with bone marrow derived MSCs in the intramuscular islet transplantation (2014)
  • Author(s): Yoshimatsu G, Sakata N, Tsuchiya H, Fukase M, Hata T, Katayose Y, Egawa S, Unno M
  • Organizer: International Hepato-Pancreato-Biliary Association 2014 11^<th> World Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20140323-27
• [Presentation] 自家膵島移植とその検討 (2014)
  • Author(s): 坂田直昭、後藤昌史、吉松軍平、畠達夫、林洋毅、中川圭、山谷英之、澤田正二郎、廣田衛久、元井冬彦、江川新一、片桐秀樹、下瀬川徹、里見進、海野倫明
  • Organizer: 第41回膵・膵島移植研究会
  • Place of Presentation: 名古屋
  • Year and Date: 20140307-08
• [Presentation] マウスモデルにおける筋肉内膵島移植に対する骨髄由来間葉系幹細胞共移植の効果 (2014)
  • Author(s): 吉松軍平、坂田直昭、土屋朗之、畠達夫、深瀬正彦、青木豪、森田浩美、竹村太郎、箕輪貴司、元井冬彦、片寄友、江川新一、海野倫明
  • Organizer: 第41回膵・膵島移植研究会
  • Place of Presentation: 名古屋
  • Year and Date: 20140307-08
• [Presentation] Imaging of transplanted islets by ultrasonography (2013)
  • Author(s): Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T, Unno M
  • Organizer: The 14 World Congress of the International Pancreas and Islet Transplant Association (IPITA2013)
  • Place of Presentation: Monterey, USA
  • Year and Date: 20130924-27
• [Presentation] Intramuscular co-transplantation of islets and bone marrow derived mesenchymal stem cells in rodent model (2013)
  • Author(s): Yoshimatsu G, Sakata N, Tsuchiya H, Hata T, Fukase M, Motoi F, Katayose Y, Egawa S, Unno M
  • Organizer: The 14^<th> World Congress of the International Pancreas and Islet Transplant Association (IPITA2013)
  • Place of Presentation: Monterey, USA
  • Year and Date: 20130924-27
• [Presentation] Transplant efficacy : understanding the effectiveness of islet transplantation (2013)
  • Author(s): Tsuchiya H, Sakata N, Yoshimatsu G, Unno M
  • Organizer: The 14^<th> World Congress of the International Pancreas and Islet Transplant Association (IPITA2013)
  • Place of Presentation: Monterey, USA
  • Year and Date: 20130924-27
• [Presentation] Postoperative cholangitis and liver dysfunction after total pancreatectomy with biliary reconstruction impair the function of autotransplanted islets (2013)
  • Author(s): Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
  • Organizer: The 14^<th> World Congress of the International Pancreas and Islet Transplant Association (IPITA2013)
  • Place of Presentation: Monterey, USA
  • Year and Date: 20130924-27
• [Presentation] 膵島移植の成績向上を目指して : 当研究グループの取り組み (2013)
  • Author(s): 坂田直昭、吉松軍平、土屋朗之、畠達夫、青木豪、水間正道、中川圭、林洋毅、元井冬彦、内藤剛、片寄友、海野倫明
  • Organizer: 第49回日本移植学会総会
  • Place of Presentation: 京都
  • Year and Date: 20130905-07
• [Presentation] Efficacy of intramuscular islet transplantation (2013)
  • Author(s): Tsuchiya H, Sakata N, Yoshimatsu G, Unno M
  • Organizer: The 13^<th> Congress of the Asian Society of Transplantation (CAST2013)
  • Place of Presentation: Kyoto
  • Year and Date: 20130902-06
• [Presentation] Bone Marrow and Mesenchymal Stem Cell Transplantation for Islet Transplantation (2013)
  • Author(s): Sakata N, Yoshimatsu G, Tsuchiya H, Fukase M, Hata T, Unno M
  • Organizer: ASahct2013
  • Place of Presentation: Sendai
  • Year and Date: 20130827-28
• [Presentation] 門脈内膵島移植の問題と新たな移植部位の確立に向けて (2013)
  • Author(s): 坂田直昭、吉松軍平、土屋朗之、青木豪、川口桂、薮内伸一、深瀬耕二、大塚英郎、乙供茂、水間正道、岡田恭穂、中川圭、林洋毅、森川孝則、吉田寛、元井冬彦、内藤剛、片寄友、江川新一、海野倫明
  • Organizer: 第44回日本膵臓総会
  • Place of Presentation: 仙台
  • Year and Date: 20130725-26
• [Presentation] 間葉系幹細胞破水等移植成績を向上させる光となるか (2013)
  • Author(s): 坂田直昭、吉松軍平、土屋朗之、畠達夫、深瀬正彦、青木豪、石田晶玄、元井冬彦、片寄友、海野倫明
  • Organizer: 第68回日本消化器外科学会総会
  • Place of Presentation: 宮崎
  • Year and Date: 20130717-19
• [Presentation] 移植膵島の超音波画像 (2013)
  • Author(s): 坂田直昭、後藤昌史、小玉哲也、元井冬彦、水間正道、吉松軍平、青木豪、深瀬耕二、大塚英郎、乙供茂、岡田恭穂、中川圭、林洋毅、森川孝則、吉田寛、内藤剛、三浦康、片寄友、里見進、海野倫明
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20130411-13
• [Presentation] ドナー膵の機能評価を予見するためのCT所見に関する検討 (2013)
  • Author(s): 坂田直昭、江川新一、力山敏樹、吉松軍平、元井冬彦、三浦康、片寄友、海野倫明
  • Organizer: 第40回日本膵・膵島移植研究会
  • Place of Presentation: 高松
  • Year and Date: 20130301-02
• [Presentation] 本邦における自家膵島移植の適応に関する検討 (2013)
  • Author(s): 坂田直昭、吉松軍平、海野倫明
  • Organizer: 第40回日本膵・膵島移植研究会
  • Place of Presentation: 高松
  • Year and Date: 20130301-02
• [Presentation] 当科における慢性膵炎に対する取り組み (2013)
  • Author(s): 坂田直昭、元井冬彦、吉田寛、内藤剛、三浦康、廣田衛久、正宗淳、片寄友、江川新一、下瀬川徹、海野倫明
  • Organizer: 第194回日本消化器病学会東北支部例会
  • Place of Presentation: 仙台
  • Year and Date: 2013-02-09
• [Presentation] Surgical treatment for chronic pancreatitis, discussion of drainage and total pancreatectomy with islet autotransplantation (2012)
  • Author(s): Sakata N, Yoshimatsu G, Aoki T, Ishida M, Fukase K, Ottomo S, Mizuma M, Okada T, Nakagawa K, Hayashi H, Morikawa T, Yoshida H, Motoi F, Naitoh T, Katayose Y, Miura K, Egawa S, Unno M
  • Organizer: 2012 Joint American Pancreatic Association (APA) / International Association of Pancreatology (IAP) Annual Meeting
  • Place of Presentation: Miami, USA
  • Year and Date: 20121031-1103
• [Presentation] Intraoperative ultrasound examination is useful for monitoring transplanted islets (2012)
  • Author(s): Sakata N, Goto M, Yoshimatsu G, Mizuma M, Motoi F, Satomi S, Unno M
  • Organizer: XXIV International Cogress of The Transplantation Society
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20120715-19
• [Remarks] ReaD & Researchship
  • URL: http://researchmap.jp/read0154889/