2013 Fiscal Year Final Research Report
Anti tumor effect of micro RNA transferred by active targeting liposomes
| Project/Area Number |
24659590
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Shinichi 岡山大学, 大学院医歯薬学総合研究科, 教授 (30397880)
OOHASHI Toshitaka 岡山大学, 大学院医歯薬学総合研究科, 准教授 (50194262)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 外科 / 発現制御 / 細胞・組織 |
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| Research Abstract |
Lung cancer and malignant pleural mesothelioma are refractory disease. Particularly, establishment of new effective therapies are urgent business to improve prognosis of inoperable tumor with the metastasis.
We have discovered microRNA (miRNA) which works inhibitory to these diseases and aimed at the establishment of active targeting liposome (lip) to accumulate to tumor cells selectively. In this study, we planned to evaluate the accumulation of the lip for the cultured tumor cells and the mouse subcutaneous tumor models for the first and the antitumor effect of the miRNA-lip the second.
At first, expected enough accumulation of the lip were not observed with cells and mouse models either, but we were successful for improvement of the accumulation efficiency by improving the lip, administration condition, and model construction methods in detail. However we spent most of the period by these processes, evaluation of the lip taking into cells and developing miRNA-lip are future problems.
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[Journal Article] ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor2014
Author(s)
Inagaki J, Takahashi K, Ogawa H, Asano K, Faruk Hatipoglu O, Cilek MZ, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S
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Journal Title
Exp Cell Res
Volume: 323
Pages: 263-275
DOI
Peer Reviewed
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[Journal Article] ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse2013
Author(s)
Demircan K, Yonezawa T, Takigawa T, Topcu V, Erdogan S, Ucar F, Armutcu F, Yigitoglu MR, Ninomiya Y, Hirohata S
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Journal Title
Neurosci Lett
Volume: 544
Pages: 25-30
DOI
Peer Reviewed
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[Journal Article] Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis2012
Author(s)
Obika M, Ogawa H, Takahashi K, Li J, Hatipoglu OF, Cilek MZ, Miyoshi T, Inagaki J, Ohtsuki T, Kusachi S, Ninomiya Y, Hirohata S
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Journal Title
Cancer Sci
Volume: 103(10)
Pages: 1889-1897
DOI
Peer Reviewed
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