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2013 Fiscal Year Final Research Report

Investigation of the mechanism of enhanced lung metastasis due to exosome from tumor endothelial cells

Research Project

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Project/Area Number 24659623
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionHokkaido University

Principal Investigator

HIDA Yasuhiro  北海道大学, 大学病院, 講師 (30399919)

Co-Investigator(Kenkyū-buntansha) KAGA Kichizou  北海道大学, 北海道大学病院, 講師 (80224335)
MATSUI Yoshirou  北海道大学, 大学院医学研究科, 教授 (90219379)
KATOH Tatsuya  北海道大学, 北海道大学病院, 特任助教 (20624232)
HIDA Kyoko  北海道大学, 大学院歯学研究科, 特任准教授 (40399952)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords血管内皮細胞 / 転移 / 悪性腫瘍 / マイクロRNA
Research Abstract

We hypothesized that tumor-associated endothelial cells (TEC) facilitate tumor metastasis. We established TEC from xenograft tumor of the low metastatic malignant melanoma cell , A375 and from that of high metastatic counter part, A375SM("super metasitatic"). Comparison of those 2 TEC revealed specific up regulation of some microRNA in A375SM TEC. Transfection of the microRNA change the phenotype of normal endothelial cells from normal skin to that of A375SM TEC.

  • Research Products

    (3 results)

All 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Heterogeneity of tumor endothelial cells2013

    • Author(s)
      Hida K., Ohga N., Akiyama K., Maishi N., Hida Y
    • Journal Title

      Cancer Sci

      Volume: 104(11) Pages: 1391-1395

    • DOI

      10.1111

    • Peer Reviewed
  • [Presentation] microvesiclesを介して腫瘍細胞由来のmiRNAが血管内皮細胞へ輸送される2013

    • Author(s)
      川本泰輔,秋山廣輔,大賀則孝,間石奈湖,進藤正信,樋田泰浩,小坂展慶,落谷孝広,樋田京子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2013-10-04
  • [Remarks] 北海道大学血管生物学教室

    • URL

      http://www.den.hokudai.ac.jp/vascular-biology/

URL: 

Published: 2015-06-25  

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