2013 Fiscal Year Final Research Report
Investigation of the mechanism of enhanced lung metastasis due to exosome from tumor endothelial cells
| Project/Area Number |
24659623
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
HIDA Yasuhiro 北海道大学, 大学病院, 講師 (30399919)
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| Co-Investigator(Kenkyū-buntansha) |
KAGA Kichizou 北海道大学, 北海道大学病院, 講師 (80224335)
MATSUI Yoshirou 北海道大学, 大学院医学研究科, 教授 (90219379)
KATOH Tatsuya 北海道大学, 北海道大学病院, 特任助教 (20624232)
HIDA Kyoko 北海道大学, 大学院歯学研究科, 特任准教授 (40399952)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 血管内皮細胞 / 転移 / 悪性腫瘍 / マイクロRNA |
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| Research Abstract |
We hypothesized that tumor-associated endothelial cells (TEC) facilitate tumor metastasis. We established TEC from xenograft tumor of the low metastatic malignant melanoma cell , A375 and from that of high metastatic counter part, A375SM("super metasitatic"). Comparison of those 2 TEC revealed specific up regulation of some microRNA in A375SM TEC. Transfection of the microRNA change the phenotype of normal endothelial cells from normal skin to that of A375SM TEC.
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