Development of novel vascular anastomosis device with biodegradable stent

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659627
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Mie University
• Principal Investigator: MUTO Akihito 三重大学, 医学(系)研究科(研究院), 助教 (30600829)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 血管外科学 / 生体材料

Research Abstract

In this study, we developed the novel technique of vascular anastomosis for severe atherosclerosis patient that had difficulty in manual direct vascular suture technique. We examined to use bioabsorbable reinforcement material and cyanoacrylate.
In ex vivo study with porcine carotid artery, we confirmed better strength of biodegradable stent and bioglue method compare to conventional direct vascular suture method in both of the mechanical extension test and the water burst pressure test. On the other hand, we could not avoid acute thrombotic occlusion in vivo study with canine model. We think that we can expect for future clinical application by solving this thrombosis problem.