2014 Fiscal Year Final Research Report
Depelopment of Porphysomes photoenhancer enabled bronchoscopic photothermal ablation
Project/Area Number |
24659635
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Thoracic surgery
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Research Institution | Kochi University |
Principal Investigator |
ANAYAMA Takashi 高知大学, 教育研究部医療学系, 講師 (30403893)
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Co-Investigator(Kenkyū-buntansha) |
OKADA Hironobu 高知大学, 教育研究部医療学系, 助教 (10444770)
MIYAZAKI Ryohei 高知大学, 教育研究部医療学系, 助教 (70566489)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | photo-thermal therapy |
Outline of Final Research Achievements |
We hypothesized that the combination of the existence of photo enhancer and low dose laser irradiation can heat the target tumor selectively to kill the cancer. Systemically administrated porphysomes nano-particles accumulate in lung cancer at higher level than that of normal tissue and absorb red light energy to heat the tumor. Locally injected Indocyanine green also absorb the infra-red light energy to heat the tumor. Using lung cancer animal models, we confirmed the cytotoxic effect of the combination therapy of photo-enhancer administration and low power laser irradiation. Reflect on the promising results of the current study, we are preparing for the clinical study in the next step.
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Free Research Field |
癌の低侵襲治療
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