Depelopment of Porphysomes photoenhancer enabled bronchoscopic photothermal ablation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659635
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Kochi University
• Principal Investigator: ANAYAMA Takashi 高知大学, 教育研究部医療学系, 講師 (30403893)
• Co-Investigator(Kenkyū-buntansha): OKADA Hironobu 高知大学, 教育研究部医療学系, 助教 (10444770) ; MIYAZAKI Ryohei 高知大学, 教育研究部医療学系, 助教 (70566489)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: photo-thermal therapy

Outline of Final Research Achievements

We hypothesized that the combination of the existence of photo enhancer and low dose laser irradiation can heat the target tumor selectively to kill the cancer. Systemically administrated porphysomes nano-particles accumulate in lung cancer at higher level than that of normal tissue and absorb red light energy to heat the tumor. Locally injected Indocyanine green also absorb the infra-red light energy to heat the tumor. Using lung cancer animal models, we confirmed the cytotoxic effect of the combination therapy of photo-enhancer administration and low power laser irradiation. Reflect on the promising results of the current study, we are preparing for the clinical study in the next step.

Free Research Field

癌の低侵襲治療