2013 Fiscal Year Final Research Report
A model of the development of IDH1 mutated glioma
Project/Area Number |
24659650
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Cerebral neurosurgery
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
ARITA Hideyuki 独立行政法人国立がん研究センター, 中央病院, がん専門修練医 (60570570)
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Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Manabu 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 脳神経外科, 医長 (40448064)
YOSHIOKA Yoshichika 大阪大学, 免疫学フロンティア研究センター, 特任教授 (00174897)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | glioma / IDH1 |
Research Abstract |
This study is aimed to reveal the mechanism of the glioma development involving the mutation of isocitrate dehydrogenase 1 (IDH1). We have reveled that IDH1 mutated gliomas show specific patterns of key genetic abnormalities and that those patterns are apparently different from that of IDH1-wild tumors. These results indicated that specific combination of key genetic changes is necessary in order to establish an experimental model of IDH1 mutated gliomas.
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[Journal Article] Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis2014
Author(s)
Kinoshita M, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
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Journal Title
Neuro Oncol
Volume: 16
Pages: 728-734
DOI
Peer Reviewed
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[Journal Article] Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss2013
Author(s)
Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, Ichimura K
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Journal Title
Acta Neuropathol
Volume: 126
Pages: 267-276
DOI
Peer Reviewed
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[Presentation] Mutations in the TERT promoter are highly recurrent and upregulate TERT expression in gliomas2013
Author(s)
Hideyuki Arita, Yoshitaka Narita, Shintaro Fukushima, Kensuke Tateishi, Yuko Matsushita, Akihiko Yoshida, Yasuji Miyakita, Makoto Ohno, V. Peter Collins, Nobutaka Kawahara, Soichiro Shibui, Koichi Ichimura
Organizer
4th Quadrennial Meeting of the World Federation of Neuro-Oncology
Place of Presentation
サンフランシスコ(米国)
Year and Date
2013-11-23
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[Presentation] Different spatial distribution between GCB and non-GCB PCNSL revealed by MR group analysis of 100 cases2013
Author(s)
Kinoshita M, Sasayama T, Narita Y, Kwaguchi A, Yamashita F, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohon M, Miyakita Y, Shizui S, Hashimoto N, Yoshimine T
Organizer
4th Quadrennial Meeting of the World Federation of Neuro-Oncology
Place of Presentation
サンフランシスコ(米国)
Year and Date
2013-11-23
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[Presentation] DIFFERENTIATION BETWEEN HIGH- AND LOW-GRADE MR NON-ENHANCING GLIOMAS USING PET; COMPARISON OF 11C-METHIONINE, FDG PET, AND 11C- METHIONINE/FDG DECOUPLING SCORE2012
Author(s)
Kinoshita M, Arita H, Chiba Y, Kagawa N, Nonaka M, Kanemura Y, Kishima H, Nakajima S, Hatazawa J, Hashimoto N, Yoshimine T
Organizer
The 17th Annual Scientific Meeting of the Society for Neuro- Oncology
Place of Presentation
ワシントン(米国)
Year and Date
2012-11-17
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