Spinal cord regeneration treatment by grafting foliiculo-stellate cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659681
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya City University
• Principal Investigator: WADA Ikuo 名古屋市立大学, 医学(系)研究科(研究院), 教授 (70182970)
• Co-Investigator(Kenkyū-buntansha): WAKABAYASHI Kenjiro 名古屋市立大学, 大学院医学研究科, 助教 (20418867) ; SAKUMA Eisuke 名古屋市立大学, 大学院医学研究科, 講師 (90295585)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 再生医療

Outline of Final Research Achievements

The preservation of gap junctions between folliculo-stellate cells are mainly dependent on the testosterone from both testes and adrenal glands in adult male rats (Microsc Res Tech. 2012). The effects of leptin over the gap junction formation within the anterior pituitary glands was directly mediated by interaction with the functional leptin receptor over the folliculo-stellate cells (Microsc Res Tech. 2014). We investigated a detailed distribution and postnatal changes of the S-100 protein-positive/folliculo-stellate cells and their relationship with LH-RH nerve elements in the pars-tuberalis of pituitary gland and showed their participation in the function (Tissue Cell. 2014). The responsiveness to LHRH has a long-term refractoriness in adult rats, and that the physiological LHRH surge may be clocked in the morning due to the gap junction (Endocrinology. 2013). These findings are important for the spinal cord regeneration treatment by grafting foliiculo-stellate cells.

Free Research Field

リハビリテーション学