Role of astrocyte metabolism in the constitution of long-term memory and the molecular pharmacological effect of anesthetics

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659703
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Aichi Medical University
• Principal Investigator: KINOSHITA Hiroyuki 愛知医科大学, 医学部, 教授 (70291490)
• Co-Investigator(Kenkyū-buntansha): NARITA Minoru 星薬科大学, 薬学部, 教授 (40318613) ; HATAKEYAMA Noboru 愛知医科大学, 医学部, 教授 (70251907) ; NAKAHATA Katsutoshi 和歌山県立医科大学, 医学部, 講師 (70332971)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 揮発性麻酔薬 / 脳 / 驚愕反応

Outline of Final Research Achievements

Whether sevoflurane inhalation modulates the fear memory in young adult mice, have not been studied although neonatal exposure to this volatile anesthetic induces neurodegeneration resulting in deficits related to social behavior and/or learning disabilities. Since mice brain completes the growth during the first two weeks after birth, the current study was designed to examine whether sevoflurane exposure to four-weeks old young adult mice modifies the long-term fear memory learning ability, and if it is the case, whether F-actin constitution in the hippocampus relates to the consolidation of fear memory. Sevoflurane exposure to young adult mice accelerated the long-term horror learning ability with increased F-actin constitution in the hippocampus. These results suggest that sevoflurane amnesia may enhance fear memory consolidation resulting in psychological stress like posttraumatic stress disorder in young adults of humans.

Free Research Field

麻酔・蘇生学