Hypoxic response as a new treatment of Post cardiac arrest syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659705
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Keio University
• Principal Investigator: MINAMISHIMA Shizuka 慶應義塾大学, 医学部, 助教 (20622088)
• Co-Investigator(Kenkyū-buntansha): MINAMISHIMA Shiszuka 慶應義塾大学, 医学部, 講師 (20593966)
• Co-Investigator(Renkei-kenkyūsha): AKIKO Kubo 慶應義塾大学, 医学部, 特任講師 (50455573) ; TAKAKO Hishiki 慶應義塾大学, 医学部, 講師 (10338022) ; MAKOTO Suematsu 慶應義塾大学, 医学部, 教授 (00206385)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 低酸素応答 / 心停止 / 心肺蘇生

Outline of Final Research Achievements

We demonstrated that inhaled Nitric oxide (NO) could improve outcome after successful cardiopulmonary resuscitation (CPR) in mice. It is increasingly recognized that NO production in hypoxia correlate with HIF (hypoxia inducible factor), a transcription factor which regulate hypoxic response. The present study tried to demonstrate whether systemically activating HIF in mice could improve the outcome after CPR.
Although survival rate, neurological and cardiac function ware assessed after cardiac arrest and CPR, HIF activation did not work to improve outcome after CPR.

Free Research Field

医歯薬学