2012 Fiscal Year Final Research Report
Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin
| Project/Area Number |
24659730
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yukiyasu 京都大学, 医学研究科, 講師 (00508236)
HORIE Akihito 京都大学, 医学研究科, 助教 (30535836)
HATTORI Akira 京都大学, 薬学研究科, 准教授 (50300893)
ARAKI Yosihiko 順天堂大学, 医学研究科, 准教授 (70250933)
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| Project Period (FY) |
2012
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| Keywords | ヒト絨毛外栄養膜細胞 / laeverin / 免疫寛容 / 胚シグナル |
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| Research Abstract |
During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.
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Research Products
(8 results)
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[Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell.2013
Author(s)
Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H and Araki Y
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Journal Title
Cancer Biomark
Volume: 13
Pages: 141-8
Peer Reviewed
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