Development of a new marker to predict pregnancy-Induced hypertension in the cervical mucus

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659735
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Nara Medical University
• Principal Investigator: TSUNEMI TAIHEI 奈良県立医科大学, 医学部, 助教 (20599831)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Hiroshi 奈良県立医科大学, 産婦人科, 教授 (40178330) ; NARUSE Katsuhiko (70453165)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 妊娠高血圧症候群

Outline of Final Research Achievements

Pregnancy Induced Hypertension (PIH) is perinatal complications that result in poor outcome and subsequent complications for mothers or babies. For the prediction of onset of PIH, we attempted the development of a new PIH onset prediction marker by focusing on cervical mucus. Oxidative stress proteins were measured in the cervical mucus, however, no significant results were obtained. One of the causes of PIH is reduced infiltration of trophoblastic cell . It was confirmed that the initial infiltration of villus cells was controlled by uPA system, including serine protease and low-oxygen environment.

Free Research Field

産科