Innate immunity in ocular pharmacology

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659765
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kagoshima University
• Principal Investigator: SAKAMOTO Taiji 鹿児島大学, 医歯(薬)学総合研究科, 教授 (10235179)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬物治療 / 自然免疫 / 網膜

Outline of Final Research Achievements

First, triamcinolone-associated sterile inflammation was studied. Granular materials including triamcinolone acetate was co-incubated wth retinal pigment epithelial cells or R28 retinal cells. As a result, inflammatory cytokines including interleukin-1 beta was significantly upregulated in a time and dose dependent mannter. Next, the effect of cell debris was studied. The histone H3 was added to these cells resulting in upregulation of inflammatory cytokines. Moreover, the excessive amount of histones induced apoptosis. Peculiarly, these negative effects were inhibited by vitreous body or hyaluronic acid. These phenomenon was mediated through toll-like receptors. Therefore, innate immunity supposedly plays a certain role in the pathology of retinal diseases.

Free Research Field

眼科