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2013 Fiscal Year Final Research Report

Nucleophosmin: immunoactivity as a novel alarmin

Research Project

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Project/Area Number 24659804
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Emergency medicine
Research InstitutionOsaka Institute of Technology

Principal Investigator

KAWAHARA Ko-ichi  大阪工業大学, 工学部, 教授 (10381170)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Ikuro  鹿児島大学, 大学院医歯(薬)学総合研究科, 特任教授 (20082282)
HASHIGUCHI Teruto  鹿児島大学, 大学院医歯(薬)学総合研究科, 教授 (70250917)
ITO Takashi  鹿児島大学, 大学院医歯(薬)学総合研究科, 特任講師 (20381171)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsヌクレオフォスミン / アラーミン / 免疫活性化 / ファゴサイトーシス
Research Abstract

Nucleophosmin is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Alarmins are endogenous molecules released from activated cells and/or dying cells, which activate the immune system and cause severe damage to cells and tissue organs. Recently, the nucleophosmin is released from endotoxin-stimulated RAW264.7 cells and induces cytokines, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin as a alarmin remains unclear. In this study, we found that the nucleophosmin-stimulated RAW264.7 cells significantly enhanced phagocytosis with flowcytometry. Furthermore, the nuclephosmin enhanced phagocytosis in in a dose-dependent fashion. Our findings suggest that nucleophosmin may be an alarmin.

  • Research Products

    (25 results)

All 2014 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (6 results) Book (3 results)

  • [Journal Article] Upregulation of non-βCell-derived Vascular Endothelial Growth Factor A Increases Small Clusters of Insulin-producing Cells in the Pancreas2014

    • Author(s)
      Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga N, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K, Sakamoto T, Maruyama I, Hashiguchi T
    • Journal Title

      Exp Clin Endocrinol Diabetes

      Volume: 122(5) Pages: 308-15

    • DOI

      10.1055/s-0034-1371811

    • Peer Reviewed
  • [Journal Article] Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions : an in vitro flow chamber model2014

    • Author(s)
      Hosokawa K, Ohnishi T, Sameshima H, Miura N, Koide T, Maruyama I, Tanaka KA
    • Journal Title

      PLoS One

      Volume: 9(1) Pages: 86491

    • DOI

      10.1371/journal.pone.0086491

    • Peer Reviewed
  • [Journal Article] Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions2014

    • Author(s)
      Hosokawa K, Ohnishi T, Miura N, Sameshima H, Koide T, Tanaka KA, Maruyama I
    • Journal Title

      Thromb Res

      Volume: 133(1) Pages: 66-72

    • DOI

      10.1016/j.thromres.2013.10.037

    • Peer Reviewed
  • [Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism2013

    • Author(s)
      Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
    • Journal Title

      PLoS One

      Volume: 8(9) Pages: 75961

    • DOI

      10.1371/journal.pone.0075961

    • Peer Reviewed
  • [Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke2013

    • Author(s)
      Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, Maruyama I, Murai Y, Tanaka E
    • Journal Title

      Int J Mol Sci

      Volume: 14(9) Pages: 18899-924

    • DOI

      10.3390/ijms140918899

  • [Journal Article] Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats2013

    • Author(s)
      Sarikaphuti A, Nararatwanchai T, Hashiguchi T, Ito T, Thaworanunta S, Kikuchi K, Oyama Y, Maruyama I, Tancharoen S
    • Journal Title

      Exp Ther Med

      Volume: 6(3) Pages: 689-695

    • URL

      http://www.spandidos-publications.com/etm/

    • Peer Reviewed
  • [Journal Article] Saturated fatty acid palmitate induces extracellular release of histone H3 : a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis2013

    • Author(s)
      Shrestha C, Ito T, Kawahara K, Shrestha B, Yamakuchi M, Hashiguchi T, Maruyama I
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437(4) Pages: 573-578

    • DOI

      10.1016/j.bbrc.2013.06.117

    • Peer Reviewed
  • [Journal Article] Coagulation activity and white thrombus formation in the microminipig2013

    • Author(s)
      Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Shameshima H, Miyoshi N, Tanimoto A, Maruyama I
    • Journal Title

      In Vivo

      Volume: 27(3) Pages: 357-61

    • URL

      http://iv.iiarjournals.org

    • Peer Reviewed
  • [Journal Article] Hemoadsorption of high-mobility group box chromosomal protein 1 using a column for large animals2013

    • Author(s)
      Nishiyama R, Shinoda M, Tanabe M, Oshima G, Takano K, Miyasho T, Fuchimoto Y, Yamada S, Inoue T, Shimada K, Suda K, Tanaka M, Hayashida T, Yagi H, Kitago M, Obara H, Itano O, Takeuchi H, Kawachi S, Maruyama I, Kitagawa Y
    • Journal Title

      Eur Surg Res

      Volume: 51(3-4) Pages: 181-90

    • DOI

      10.1159/000357563

  • [Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma2013

    • Author(s)
      Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K
    • Journal Title

      Brain Tumor Pathol

      Volume: 30(1) Pages: 28-33

    • DOI

      10.1007/s10014-012-0095-z

    • Peer Reviewed
  • [Journal Article] Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions2013

    • Author(s)
      Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I
    • Journal Title

      Thromb Haemost

      Volume: 109(1) Pages: 102-11

    • DOI

      10.1160/TH12-06-0441

    • Peer Reviewed
  • [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012

    • Author(s)
      Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y
    • Journal Title

      Atherosclerosis

      Volume: 224(2) Pages: 511-4

    • DOI

      10.1016/j.atherosclerosis.2012.07.027

    • Peer Reviewed
  • [Journal Article] Efficacy of MK615 for the treatment of patients with liver disorders2012

    • Author(s)
      Hokari A, Ishikawa T, Tajiri H, Matsuda T, Ishii O, Matsumoto N, Okuse C, Takahashi H, Kurihara T, Kawahara K, Maruyama I, Zeniya M
    • Journal Title

      World J Gastroenterol

      Volume: 18(31) Pages: 4118-26

    • DOI

      10.3748/wjg.v18.i31.4118

    • Peer Reviewed
  • [Journal Article] Secondary prevention of stroke : Pleiotropic effects of optimal oral pharmacotherapy2012

    • Author(s)
      Kikuchi K, Kawahara K, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Hirohata M, Maruyama I, Morioka M, Tanaka E
    • Journal Title

      Exp Ther Med

      Volume: 4(1) Pages: 3-7

    • URL

      http://www.spandidos-publications.com/etm/

    • Peer Reviewed
  • [Journal Article] MK615, a Prunus mume Steb. Et Zucc ('Ume') extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway2012

    • Author(s)
      Tada K, Kawahara K, Matsushita S, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Phytother Res

      Volume: 26(6) Pages: 833-8

    • DOI

      10.1002/ptr.3645

    • Peer Reviewed
  • [Journal Article] Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease2012

    • Author(s)
      Yoshifuku A, Oyama K, Ibusuki A, Kawasaki M, Sakanoue M, Matsushita S, Kawai K, Kawahara K, Maruyama I, Kanekura T
    • Journal Title

      Clin Exp Dermatol

      Volume: 37(3) Pages: 241-4

    • DOI

      10.1111/j.1365-2230.2011.04181.x

    • Peer Reviewed
  • [Presentation] イチゴエキスはHMGB1の放出を抑制する2013

    • Author(s)
      大池加恵、上村龍平、丸山征郎、川原幸一
    • Organizer
      2013年度日本生物高分子学会
    • Place of Presentation
      大阪
    • Year and Date
      2013-11-20
  • [Presentation] マクロファージにおけるプロスタグランジン合成酵素の誘導2013

    • Author(s)
      井上智博、川原幸一、松村潔
    • Organizer
      2013年度日本生物高分子学会
    • Place of Presentation
      大阪
    • Year and Date
      2013-11-20
  • [Presentation] 炎症に起因する血栓症の病態解明~新規メディエーターとしてのPAMPs・DAMPs~2013

    • Author(s)
      伊藤隆史
    • Organizer
      第35回血栓止血学会
    • Place of Presentation
      山形
    • Year and Date
      2013-05-30
  • [Presentation] イチゴの新規機能 : HMGB1放出抑制2012

    • Author(s)
      上村龍平、大池加恵、丸山征郎、川原幸一
    • Organizer
      第85回生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
  • [Presentation] イチゴの新規機能 : HMGB1放出抑制2012

    • Author(s)
      上村龍平、大池加恵、丸山征郎、川原幸一
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
  • [Presentation] イチゴの新規機能 : HMGB1放出抑制2012

    • Author(s)
      上村龍平、大池加恵、丸山征郎、川原幸一
    • Organizer
      第51回日本栄養・食糧学会近畿支部大会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-10-20
  • [Book] 別冊BIO Clinica慢性炎症と疾患骨髄-末梢血による炎症の制御と修飾血小板-好中球のサティリティズムと炎症2013

    • Author(s)
      大池加恵、川原幸一
    • Total Pages
      78-83
    • Publisher
      北隆館
  • [Book] 特集PAMPs/DAMPsと血栓症DIC NETsとヒストンThrombosis medicine 3(4)2013

    • Author(s)
      大池加恵、川原幸一
    • Total Pages
      334-338
    • Publisher
      先端医学社
  • [Book] 特集"自然"炎症と凝固・血小板系のクロストーク(第4回) NETs(Neutorophil Extracellular Traps)と血栓症Thrombosis medicine 2(3)2012

    • Author(s)
      上村龍平、川原幸一
    • Total Pages
      271-274
    • Publisher
      先端医学社

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Published: 2015-06-25  

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