2013 Fiscal Year Final Research Report
Nucleophosmin: immunoactivity as a novel alarmin
| Project/Area Number |
24659804
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro 鹿児島大学, 大学院医歯(薬)学総合研究科, 特任教授 (20082282)
HASHIGUCHI Teruto 鹿児島大学, 大学院医歯(薬)学総合研究科, 教授 (70250917)
ITO Takashi 鹿児島大学, 大学院医歯(薬)学総合研究科, 特任講師 (20381171)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ヌクレオフォスミン / アラーミン / 免疫活性化 / ファゴサイトーシス |
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| Research Abstract |
Nucleophosmin is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Alarmins are endogenous molecules released from activated cells and/or dying cells, which activate the immune system and cause severe damage to cells and tissue organs. Recently, the nucleophosmin is released from endotoxin-stimulated RAW264.7 cells and induces cytokines, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin as a alarmin remains unclear. In this study, we found that the nucleophosmin-stimulated RAW264.7 cells significantly enhanced phagocytosis with flowcytometry. Furthermore, the nuclephosmin enhanced phagocytosis in in a dose-dependent fashion. Our findings suggest that nucleophosmin may be an alarmin.
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Research Products
(25 results)
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[Journal Article] Upregulation of non-βCell-derived Vascular Endothelial Growth Factor A Increases Small Clusters of Insulin-producing Cells in the Pancreas2014
Author(s)
Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga N, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K, Sakamoto T, Maruyama I, Hashiguchi T
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Journal Title
Exp Clin Endocrinol Diabetes
Volume: 122(5)
Pages: 308-15
DOI
Peer Reviewed
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[Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism2013
Author(s)
Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
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Journal Title
PLoS One
Volume: 8(9)
Pages: 75961
DOI
Peer Reviewed
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[Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke2013
Author(s)
Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, Maruyama I, Murai Y, Tanaka E
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Journal Title
Int J Mol Sci
Volume: 14(9)
Pages: 18899-924
DOI
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[Journal Article] Hemoadsorption of high-mobility group box chromosomal protein 1 using a column for large animals2013
Author(s)
Nishiyama R, Shinoda M, Tanabe M, Oshima G, Takano K, Miyasho T, Fuchimoto Y, Yamada S, Inoue T, Shimada K, Suda K, Tanaka M, Hayashida T, Yagi H, Kitago M, Obara H, Itano O, Takeuchi H, Kawachi S, Maruyama I, Kitagawa Y
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Journal Title
Eur Surg Res
Volume: 51(3-4)
Pages: 181-90
DOI
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[Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma2013
Author(s)
Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K
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Journal Title
Brain Tumor Pathol
Volume: 30(1)
Pages: 28-33
DOI
Peer Reviewed
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[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012
Author(s)
Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y
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Journal Title
Atherosclerosis
Volume: 224(2)
Pages: 511-4
DOI
Peer Reviewed
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[Journal Article] Efficacy of MK615 for the treatment of patients with liver disorders2012
Author(s)
Hokari A, Ishikawa T, Tajiri H, Matsuda T, Ishii O, Matsumoto N, Okuse C, Takahashi H, Kurihara T, Kawahara K, Maruyama I, Zeniya M
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Journal Title
World J Gastroenterol
Volume: 18(31)
Pages: 4118-26
DOI
Peer Reviewed
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[Journal Article] Secondary prevention of stroke : Pleiotropic effects of optimal oral pharmacotherapy2012
Author(s)
Kikuchi K, Kawahara K, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Hirohata M, Maruyama I, Morioka M, Tanaka E
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Journal Title
Exp Ther Med
Volume: 4(1)
Pages: 3-7
URL
Peer Reviewed
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