2014 Fiscal Year Final Research Report
Identification of neural crest-derived cells to use for the analysis of disease mechanism and regenerative medicine
| Project/Area Number |
24659830
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 再生 / 神経堤 / 骨 / 細胞分化 / 幹細胞 / 骨芽細胞 / 上皮細胞 / マウス |
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| Outline of Final Research Achievements |
Neural crest cells appear during embryogenesis and differentiate into various kinds of cells, which reside as stem cells even after growth. Thus, neural crest stem cells are expected to be used as cell source for regenerative medicine. However, precise locarization of neural crest-derived cells has not been known. In this study, we tried to identify new cell populations that derived from neural crest by using double transgenic mice in which neural crest-derived cells are labeled with a green fluorescence protein. We found that a part of keratinocytes are derived from neural crest cells but not epidermal stem cells. These findings suggest that neural crest-derived cells in the epidermal tissues may be useful for regenerative medicine.
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| Free Research Field |
歯科薬理学
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