Development of real-time image analysis system of cervical lymph node network using nanobubbles

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659834
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohoku University
• Principal Investigator: SAKAMOTO Maya 東北大学, 大学病院, 講師 (90157686)
• Co-Investigator(Kenkyū-buntansha): KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986) ; IIKUBO Masahiro 東北大学, 歯学研究科, 講師 (80302157) ; KOJIMA Ikuho 東北大学, 歯学研究科, 助教 (80447169)
• Co-Investigator(Renkei-kenkyūsha): MORI Shiro 東北大学, 大学病院, 講師 (80230069)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ナノバブル / 超音波 / リンパネットワーク / 画像解析

Outline of Final Research Achievements

The aim of this study is to develop a new diagnostic imaging technique which can detect the head and neck cancer metastasis routes. In this study, MXH10 / Mo / lpr mice,　which develop systemic swelling of lymph nodes up to 10 mm in diameter,　were used as a lymph node metastasis model.　As a method for visualization of lymph node network in real time, we examined a contrast ultrasound imaging system using nano-microbubbles.　As a result, it was suggested that contrast ultrasound image analysis method using a nano-micro-bubbles might be a potential method clinically applicable to detection of lymphatic network.

Free Research Field

医歯薬学